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Details on Person Kdm6a (Utx) demethylates trimethylated histone H3 lysine-27 (H3K27me3)

Class:Id	Reaction:9822964
_displayName	Kdm6a (Utx) demethylates trimethylated histone H3 lysine-27 (H3K27me3)
_doRelease	TRUE
_timestamp	2026-03-13 14:29:00
authored	[InstanceEdit:9822777] May, Bruce, 2022-12-28
catalystActivity	[CatalystActivity:9822919] histone H3K27me2/H3K27me3 demethylase activity of Kdm6a:Fe2+ [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9822949] May, Bruce, 2023-01-03
crossReference	[DatabaseIdentifier:9985018] RHEA:60225
edited	[InstanceEdit:9822777] May, Bruce, 2022-12-28
input	[DefinedSet:5617937] Histone H3 (H3K27me3) [nucleoplasm] [Mus musculus] [SimpleEntity:113671] 2OG [nucleoplasm] [SimpleEntity:113671] 2OG [nucleoplasm] [SimpleEntity:113685] O2 [nucleoplasm] [SimpleEntity:113685] O2 [nucleoplasm]
isChimeric	FALSE
literatureReference	[LiteratureReference:9822975] Histone Demethylase UTX is an Essential Factor for Zygotic Genome Activation and Regulates Zscan4 Expression in Mouse Embryos
modified	[InstanceEdit:9841053] May, Bruce, 2023-08-07 [InstanceEdit:9841067] May, Bruce, 2023-08-08 [InstanceEdit:9984987] Stephan, Ralf, 2026-03-13
name	Kdm6a (Utx) demethylates trimethylated histone H3 lysine-27 (H3K27me3)
output	[DefinedSet:9822990] Histone H3 (H3K27me1) [nucleoplasm] [Mus musculus] [SimpleEntity:29478] CH2O [nucleoplasm] [SimpleEntity:29478] CH2O [nucleoplasm] [SimpleEntity:159942] CO2 [nucleoplasm] [SimpleEntity:159942] CO2 [nucleoplasm] [SimpleEntity:159939] SUCCA [nucleoplasm] [SimpleEntity:159939] SUCCA [nucleoplasm]
releaseDate	2023-09-13
reviewed	[InstanceEdit:9841065] Xie, Wei, 2023-08-08
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48892] Mus musculus
stableIdentifier	[StableIdentifier:9822998] R-MMU-9822964.1
summation	[Summation:9822903] Kdm6a (UTX) demethylates histone H3 trimethyllysine-27 (H3K2...
(inferredFrom)	[Reaction:9822985] KDM6A (UTX) demethylates histone H3 trimethyllysine-27 (H3K27me3) [Homo sapiens]
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No pathways have been reviewed or authored by Kdm6a (Utx) demethylates trimethylated histone H3 lysine-27 (H3K27me3) (9822964)