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Details on Person METTL23 dimethylates histone H3.3 arginine-17 (arginine-18 in the preprotein)

Class:Id	Reaction:9822583
_displayName	METTL23 dimethylates histone H3.3 arginine-17 (arginine-18 in the preprotein)
_doRelease	TRUE
_timestamp	2023-08-08 18:00:51
authored	[InstanceEdit:9822581] May, Bruce, 2022-12-26
catalystActivity	[CatalystActivity:9822593] histone methyltransferase activity of METTL23 [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9822605] May, Bruce, 2022-12-26
edited	[InstanceEdit:9822581] May, Bruce, 2022-12-26
inferredFrom	[Reaction:9822592] Mettl23 dimethylates histone H3.3 arginine-18 (arginine-17 in the mature protein) [Mus musculus]
input	[EntityWithAccessionedSequence:212295] H3F3A [nucleoplasm] [Homo sapiens] [SimpleEntity:77087] AdoMet [nucleoplasm] [SimpleEntity:77087] AdoMet [nucleoplasm]
isChimeric	FALSE
modified	[InstanceEdit:9822777] May, Bruce, 2022-12-28 [InstanceEdit:9827267] May, Bruce, 2023-01-31 [InstanceEdit:9841067] May, Bruce, 2023-08-08
name	METTL23 dimethylates histone H3.3 arginine-17 (arginine-18 in the preprotein)
output	[EntityWithAccessionedSequence:9822613] H3R17me2a [nucleoplasm] [Homo sapiens] [SimpleEntity:9668967] H+ [nucleoplasm] [SimpleEntity:9668967] H+ [nucleoplasm] [SimpleEntity:77502] AdoHcy [nucleoplasm] [SimpleEntity:77502] AdoHcy [nucleoplasm]
releaseDate	2023-09-13
reviewed	[InstanceEdit:9841065] Xie, Wei, 2023-08-08
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9822619] R-HSA-9822583.1
summation	[Summation:9822776] METTL23 catalyzes the asymmetric dimethylation of arginine-1...
(hasEvent)	[Pathway:9821993] Replacement of protamines by nucleosomes in the male pronucleus [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9822185] HIRA and NPM2 assemble H3.3-containing nucleosomes on paternal DNA [Homo sapiens]
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No pathways have been reviewed or authored by METTL23 dimethylates histone H3.3 arginine-17 (arginine-18 in the preprotein) (9822583)