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Details on Person factor VIII -> factor VIIIa + factor VIII B chain+ factor VIII A3 acidic polypeptide +VWF multimer (TF:FVIIa:FXa catalyst)

Class:Id	Reaction:9822522
_displayName	factor VIII -> factor VIIIa + factor VIII B chain+ factor VIII A3 acidic polypeptide +VWF multimer (TF:FVIIa:FXa catalyst)
_doRelease	TRUE
_timestamp	2026-01-27 16:18:37
authored	[InstanceEdit:9822524] Shamovsky, Veronica, 2022-12-25
catalystActivity	[CatalystActivity:9822518] serine-type endopeptidase activity of TF:FVIIa:FXa [plasma membrane]
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:9822524] Shamovsky, Veronica, 2022-12-25
edited	[InstanceEdit:9937613] Shamovsky, Veronica, 2025-02-05
input	[Complex:158363] factor VIII:von Willebrand factor multimer [extracellular region] [Homo sapiens]
internalReviewed	[InstanceEdit:9937296] D'Eustachio, Peter, 2025-01-30 [InstanceEdit:9936123] D'Eustachio, Peter, 2025-01-20
literatureReference	[LiteratureReference:9929768] Selective factor VIII activation by the tissue factor-factor VIIa-factor Xa complex [LiteratureReference:9929761] Potential role of activated factor VIII (FVIIIa) in FVIIa/tissue factor-dependent FXa generation in initiation phase of blood coagulation [LiteratureReference:9929780] Mechanisms of factor VIIa-catalyzed activation of factor VIII [LiteratureReference:9929782] The role of proteolytic cleavage at Arg³³⁶ and Arg³⁷² of the A1 domain in factor VIIa/tissue factor-catalyzed reactions of B domain-deleted factor VIII
modified	[InstanceEdit:9929086] Shamovsky, Veronica, 2024-11-20 [InstanceEdit:9929866] Shamovsky, Veronica, 2024-11-29 [InstanceEdit:9938613] Shamovsky, Veronica, 2025-02-18 [InstanceEdit:9938672] Shamovsky, Veronica, 2025-02-18 [InstanceEdit:9938847] Shamovsky, Veronica, 2025-02-20 [InstanceEdit:9979549] Shamovsky, Veronica, 2026-01-20 [InstanceEdit:9980355] Shamovsky, Veronica, 2026-01-27
name	factor VIII -> factor VIIIa + factor VIII B chain+ factor VIII A3 acidic polypeptide +VWF multimer (TF:FVIIa:FXa catalyst) FVIII is cleaved to generate FVIIIa (TF:FVIIa:FXa catalyst)
output	[Complex:158307] factor VIIIa [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:158178] F8(1668-1708) [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:9929865] F8(760-1332) [extracellular region] [Homo sapiens] [Complex:158136] VWF multimer [extracellular region] [Homo sapiens]
precedingEvent	[BlackBoxEvent:9661625] FVIII is secreted [Homo sapiens] [Reaction:9929060] TF:FVII:FXa ->TF:FVIIa:FXa (FXa catalyst) [Homo sapiens] [Reaction:9822514] TF:FVIIa+FX -> TF:FVIIa:FXa + FX activation peptide (TF:F7a catalyst) [Homo sapiens] [Reaction:9822514] TF:FVIIa+FX -> TF:FVIIa:FXa + FX activation peptide (TF:F7a catalyst) [Homo sapiens] [Reaction:140748] tissue factor (TF) + activated factor VII (F7a) -> TF:F7a complex [Homo sapiens] [Reaction:9822512] TF:FVIIa:FXa ->TF:FVIIa + FXa [Homo sapiens]
releaseDate	2026-03-25
requiredInputComponent	[Complex:140734] TF:FVIIa [plasma membrane] [Homo sapiens]
reviewStatus	[ReviewStatus:9821383] three stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9822526] R-HSA-9822522.1
structureModified	[InstanceEdit:9929866] Shamovsky, Veronica, 2024-11-29
summation	[Summation:9822517] Small amounts of factor VIII (FVIII, F8) can be activated by...
(hasEvent)	[Pathway:9769735] Initiation of coagulation cascade [Homo sapiens]
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No pathways have been reviewed or authored by factor VIII -> factor VIIIa + factor VIII B chain+ factor VIII A3 acidic polypeptide +VWF multimer (TF:FVIIa:FXa catalyst) (9822522)