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Details on Person TF:FVII+FX -> TF:FVII:FXa + FX activation peptide (TF:F7 catalyst)

Class:Id	Reaction:9822513
_displayName	TF:FVII+FX -> TF:FVII:FXa + FX activation peptide (TF:F7 catalyst)
_doRelease	TRUE
_timestamp	2026-01-27 16:17:17
authored	[InstanceEdit:9822524] Shamovsky, Veronica, 2022-12-25
catalystActivity	[CatalystActivity:140776] serine-type endopeptidase activity of TF:F7 [plasma membrane]
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:9822524] Shamovsky, Veronica, 2022-12-25
edited	[InstanceEdit:9937613] Shamovsky, Veronica, 2025-02-05
input	[Complex:140739] factor X [extracellular region] [Homo sapiens] [Complex:140775] TF:F7 [plasma membrane] [Homo sapiens]
internalReviewed	[InstanceEdit:9936123] D'Eustachio, Peter, 2025-01-20
literatureReference	[LiteratureReference:140743] Binding of human factor VII and VIIa to monocytes [LiteratureReference:140779] Factor VII binding to tissue factor in reconstituted phospholipid vesicles: induction of cooperativity by phosphatidylserine [LiteratureReference:140782] Tissue factor and hemostasis [LiteratureReference:9841900] Conformational Plasticity-Rigidity Axis of the Coagulation Factor VII Zymogen Elucidated by Atomistic Simulations of the N-Terminally Truncated Factor VIIa Protease Domain [LiteratureReference:9671038] Structural biology of factor VIIa/tissue factor initiated coagulation
modified	[InstanceEdit:9841918] Shamovsky, Veronica, 2023-08-15 [InstanceEdit:9854637] Shamovsky, Veronica, 2023-11-28 [InstanceEdit:9938594] Shamovsky, Veronica, 2025-02-18 [InstanceEdit:9938668] Shamovsky, Veronica, 2025-02-18 [InstanceEdit:9938844] Shamovsky, Veronica, 2025-02-20 [InstanceEdit:9979536] Shamovsky, Veronica, 2026-01-20 [InstanceEdit:9980354] Shamovsky, Veronica, 2026-01-27
name	TF:FVII+FX -> TF:FVII:FXa + FX activation peptide (TF:F7 catalyst) TF:FVII converts FX into FXa activation of factor X by TF:F7
output	[EntityWithAccessionedSequence:140785] factor X activation peptide [extracellular region] [Homo sapiens] [Complex:9822515] TF:FVII:FXa [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:140783] tissue factor (TF) + factor VII (F7) -> TF:F7 complex [Homo sapiens] [Reaction:140761] sequestered tissue factor -> tissue factor [Homo sapiens]
regulatedBy	[PositiveRegulation:9854651] Positive regulation by 'APLs [external side of plasma membrane]'
regulationReference	[RegulationReference:9854654] Positive regulation by 'APLs [external side of plasma membrane]' The local phospholipid environment modulates the activation of blood clotting
releaseDate	2026-03-25
reviewStatus	[ReviewStatus:9821383] three stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9822531] R-HSA-9822513.1
structureModified	[InstanceEdit:9854637] Shamovsky, Veronica, 2023-11-28
summation	[Summation:9822521] This Reactome event describes binding of factor X (FX) to th...
(hasEvent)	[Pathway:9769735] Initiation of coagulation cascade [Homo sapiens]
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No pathways have been reviewed or authored by TF:FVII+FX -> TF:FVII:FXa + FX activation peptide (TF:F7 catalyst) (9822513)