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Details on Person Factor VIIa (FVIIa), bound to tissue factor (TF) at the endo...
| Class:Id | Summation:9822511 |
|---|---|
| _displayName | Factor VIIa (FVIIa), bound to tissue factor (TF) at the endo... |
| _timestamp | 2024-11-20 00:18:58 |
| created | [InstanceEdit:9822524] Shamovsky, Veronica, 2022-12-25 |
| literatureReference | [LiteratureReference:9841909] The tissue factor/factor VIIa/factor Xa complex: a model built by docking and site-directed mutagenesis [LiteratureReference:9841912] An all-atom solution-equilibrated model for human extrinsic blood coagulation complex (sTF-VIIa-Xa): a protein-protein docking and molecular dynamics refinement study [LiteratureReference:9841907] Recent estimates of the structure of the factor VIIa (FVIIa)/tissue factor (TF) and factor Xa (FXa) ternary complex [LiteratureReference:9671038] Structural biology of factor VIIa/tissue factor initiated coagulation [LiteratureReference:9929045] Blood coagulation factor X: molecular biology, inherited disease, and engineered therapeutics |
| modified | [InstanceEdit:9929044] Shamovsky, Veronica, 2024-11-20 |
| text | Factor VIIa (FVIIa), bound to tissue factor (TF) at the endothelial cell surface catalyzes the cleavage of factor X (FX, F10) with high efficiency within a ternary complex TF:FVIIa:FX (Norledge BV et al., 2003; Venkateswarlu D et al., 2003; reviewed in Lee CJ et al., 2010; Vadivel K & Bajaj SP 2012). The activated FXa (F10a) consists of a heavy chain (235-488) with the catalytic domain and a light chain (41-179) (reviewed in Camire RM 2021). The amino terminal part of the heavy chain of FX, factor X activation peptide (183-234), is released; this peptide has no known function). Once activated, FXa can remain associated with TF:FVIIa or may dissociate from TF:VIIa:FXa (Norledge BV et al., 2003; Venkateswarlu D et al., 2003). When released, soluble FXa binds to activated factor V (FVa). The formed prothrombinase FXa:FVa complex cleaves prothrombin (factor II) to thrombin (factor IIa), a key enzyme that further catalyzes the conversion of fibrinogen to fibrin, leading to the formation of a stable blood clot. This Reactome event shows the release of FXa from the TF:FVII:FXa complex. |
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No pathways have been reviewed or authored by Factor VIIa (FVIIa), bound to tissue factor (TF) at the endo... (9822511)
