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Details on Person CCR4-NOT deadenylates mRNA in CCR4-NOT:Btg4:Pabpn1l:mRNP

Class:Id	Reaction:9822325
_displayName	CCR4-NOT deadenylates mRNA in CCR4-NOT:Btg4:Pabpn1l:mRNP
_doRelease	TRUE
_timestamp	2023-08-08 17:53:58
authored	[InstanceEdit:9822274] May, Bruce, 2022-12-22
catalystActivity	[CatalystActivity:9822304] poly(A)-specific ribonuclease activity of CCR4-NOT:Btg4:Pabpn1l:mRNP [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9822305] May, Bruce, 2022-12-23
edited	[InstanceEdit:9822274] May, Bruce, 2022-12-22
input	[Complex:9817642] CCR4-NOT:Btg4:Pabpn1l:mRNP [cytosol] [Mus musculus]
isChimeric	FALSE
literatureReference	[LiteratureReference:9817712] BTG4 is a meiotic cell cycle-coupled maternal-zygotic-transition licensing factor in oocytes [LiteratureReference:9819212] The BTG4 and CAF1 complex prevents the spontaneous activation of eggs by deadenylating maternal mRNAs [LiteratureReference:9819228] BTG4 is a key regulator for maternal mRNA clearance during mouse early embryogenesis [LiteratureReference:9820818] PABPN1L mediates cytoplasmic mRNA decay as a placeholder during the maternal-to-zygotic transition
modified	[InstanceEdit:9822429] May, Bruce, 2022-12-23 [InstanceEdit:9841067] May, Bruce, 2023-08-08
name	CCR4-NOT deadenylates mRNA in CCR4-NOT:Btg4:Pabpn1l:mRNP
output	[Complex:9822306] CCR4-NOT:Btg4:Pabpn1l:deadenylated mRNP [cytosol] [Mus musculus] [SimpleEntity:76577] AMP [cytosol]
releaseDate	2023-09-13
reviewed	[InstanceEdit:9841065] Xie, Wei, 2023-08-08
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48892] Mus musculus
stableIdentifier	[StableIdentifier:9822383] R-MMU-9822325.1
summation	[Summation:9822426] Btg4 bound to Pabpn1l and eIF4E of the mRNP recruits the CCR...
(inferredFrom)	[Reaction:9822311] CCR4-NOT deadenylates mRNA in CCR4-NOT:BTG4:PABPN1L:mRNP [Homo sapiens]
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No pathways have been reviewed or authored by CCR4-NOT deadenylates mRNA in CCR4-NOT:Btg4:Pabpn1l:mRNP (9822325)