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Details on Person Diagram of Formation of WDR5-containing histone-modifying complexes and Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome

Class:IdPathwayDiagram:9821921
_displayNameDiagram of Formation of WDR5-containing histone-modifying complexes and Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome
_timestamp2025-05-30 15:54:57
created[InstanceEdit:9821922] Orlic-Milacic, Marija, 2022-12-15
height1879
modified[InstanceEdit:9821925] Orlic-Milacic, Marija, 2022-12-15
[InstanceEdit:9821929] Orlic-Milacic, Marija, 2022-12-15
[InstanceEdit:9822169] Orlic-Milacic, Marija, 2022-12-19
[InstanceEdit:9822170] Orlic-Milacic, Marija, 2022-12-19
[InstanceEdit:9823260] Orlic-Milacic, Marija, 2023-01-04
[InstanceEdit:9823261] Orlic-Milacic, Marija, 2023-01-04
[InstanceEdit:9828243] Orlic-Milacic, Marija, 2023-02-11
[InstanceEdit:9829015] Orlic-Milacic, Marija, 2023-02-21
[InstanceEdit:9945031] Orlic-Milacic, Marija, 2025-04-08
[InstanceEdit:9953265] Orlic-Milacic, Marija, 2025-05-30
representedPathway[Pathway:9772755] Formation of WDR5-containing histone-modifying complexes [Homo sapiens]
[Pathway:9944997] Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome [Homo sapiens]
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</org.gk.render.RenderableEntitySet> <org.gk.render.RenderableProtein id="1663" reactomeId="3321875" position="674 1471" bounds="647 1460 54 22" textPosition="650 1453"> <Properties> <displayName>KANSL1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="1664" reactomeId="3321845" position="685 1627" bounds="668 1617 35 21" textPosition="669 1617"> <Properties> <displayName>OGT</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableEntitySet id="1665" reactomeId="9828237" position="1022 1556" bounds="998 1542 49 28" textPosition="1007 1545" bgColor="204 255 255" fgColor="0 0 0" lineColor="0 0 0" lineWidth="1.0"> <Properties> <displayName>NSL</displayName> </Properties> </org.gk.render.RenderableEntitySet> </Nodes> <Edges> <org.gk.render.RenderableReaction id="6" reactomeId="9675214" points="610 549, 646 550, 702 550" position="646 550" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="7" points="580 596" /> <Input id="9" points="572 506" /> <Input id="14" points="545 548" /> </Inputs> <Outputs> <Output id="11" /> </Outputs> <Properties> <displayName>Formation of the WRAD complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="15" reactomeId="9675215" points="367 547, 408 546, 452 547" position="408 546" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="8" points="322 518" /> <Input id="10" points="323 566" /> </Inputs> <Outputs> <Output id="14" /> </Outputs> <Properties> <displayName>Formation of the RBBP5:ASH2L heterodimer</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="19" reactomeId="9675026" points="879 531, 913 540, 983 533" position="913 540" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="11" points="805 542" /> <Input id="841" points="840 464" /> </Inputs> <Outputs> <Output id="21" /> </Outputs> <Properties> <displayName>Formation of the MLL1 complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="52" reactomeId="9676255" points="899 622, 931 627, 1000 623" position="931 627" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="11" points="775 564" /> <Input id="868" points="886 584" /> </Inputs> <Outputs> <Output id="54" /> </Outputs> <Properties> <displayName>Formation of the MLL2 complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="55" reactomeId="9676254" points="876 741, 950 737, 1029 726" position="950 737" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="11" points="760 564" /> <Input id="56" points="870 679" /> </Inputs> <Outputs> <Output id="57" /> </Outputs> <Properties> <displayName>Formation of the MLL3 complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="58" reactomeId="9676268" points="845 766, 950 928, 1037 933" position="950 928" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="11" points="757 564" /> <Input id="53" points="953 775" /> </Inputs> <Outputs> <Output id="60" /> </Outputs> <Properties> <displayName>Formation of the MLL4 complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="61" reactomeId="9676257" points="834 987, 935 982, 1019 981" position="935 982" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="11" points="755 564" /> <Input id="62" points="870 899" /> </Inputs> <Outputs> <Output id="63" /> </Outputs> <Properties> <displayName>Formation of the SET1A complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="64" reactomeId="9676264" points="812 1164, 913 1159, 1005 1167" position="913 1159" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="11" points="754 564" /> <Input id="65" points="850 1051" /> </Inputs> <Outputs> <Output id="66" /> </Outputs> <Properties> <displayName>Formation of the SET1B complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="139" reactomeId="9677050" points="579 837, 608 836, 659 833" position="608 836" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="140" points="315 1005" /> <Input id="7" points="574 624" /> <Input id="141" points="656 667" /> <Input id="142" points="353 772" /> <Input id="143" points="367 1118" /> <Input id="144" points="310 942" /> <Input id="145" points="331 885" /> <Input id="146" points="403 748" /> <Input id="147" points="321 1077" /> <Input id="148" points="335 823" /> </Inputs> <Outputs> <Output id="149" /> </Outputs> <Properties> <displayName>Formation of the GCN5-ATAC complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="150" reactomeId="9677051" points="470 1039, 520 1042, 594 1041" position="520 1042" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="140" points="327 1021" /> <Input id="7" points="571 624" /> <Input id="142" points="330 780" /> <Input id="143" points="372 1118" /> <Input id="144" points="307 970" /> <Input id="145" points="317 904" /> <Input id="146" points="386 754" /> <Input id="147" points="340 1082" /> <Input id="151" points="466 1151" /> <Input id="148" points="321 837" /> </Inputs> <Outputs> <Output id="152" /> </Outputs> <Properties> <displayName>Formation of the PCAF-ATAC complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="829" reactomeId="9818574" points="847 81, 849 107, 836 153" position="849 107" lineWidth="1.0"> <Inputs> <Input id="830" /> </Inputs> <Outputs> <Output id="831" /> </Outputs> <Catalysts> <Catalyst id="832" points="774 86" /> </Catalysts> <Properties> <displayName>TASP1 cleaves KMT2A</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="840" reactomeId="9818576" points="833 181, 833 227, 833 436" position="833 227" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="831" /> </Inputs> <Outputs> <Output id="841" /> </Outputs> <Properties> <displayName>Cleaved KMT2A dimers translocate to the nucleus</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="864" reactomeId="9818577" points="647 76, 654 107, 655 152" position="654 107" lineWidth="1.0"> <Inputs> <Input id="865" /> </Inputs> <Outputs> <Output id="866" /> </Outputs> <Catalysts> <Catalyst id="832" points="722 87" /> </Catalysts> <Properties> <displayName>TASP1 cleaves KMT2B</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="871" reactomeId="9818578" points="655 180, 655 224, 743 468, 867 556" position="655 224" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="866" /> </Inputs> <Outputs> <Output id="868" /> </Outputs> <Properties> <displayName>Cleaved KMT2B dimers translocate to the nucleus</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="960" interactionType="Activate" points="1081 530, 2345 585, 2135 1567" position="2345 585" lineWidth="2.0"> <Inputs> <Input id="21" /> </Inputs> <Outputs> <Output id="959" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="961" interactionType="Activate" points="1098 621, 2267 639, 2132 1567" position="2267 639" lineWidth="2.0"> <Inputs> <Input id="54" /> </Inputs> <Outputs> <Output id="959" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="962" interactionType="Activate" points="1127 722, 2346 760, 2136 1567" position="2346 760" lineWidth="2.0"> <Inputs> <Input id="57" /> </Inputs> <Outputs> <Output id="959" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="963" interactionType="Activate" points="1135 935, 2156 926, 2129 1567" position="2156 926" lineWidth="2.0"> <Inputs> <Input id="60" /> </Inputs> <Outputs> <Output id="959" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="964" interactionType="Activate" points="1124 981, 2119 985, 2127 1567" position="2119 985" lineWidth="2.0"> <Inputs> <Input id="63" /> </Inputs> <Outputs> <Output id="959" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="965" interactionType="Activate" points="1109 1173, 2101 1210, 2125 1567" position="2101 1210" lineWidth="2.0"> <Inputs> <Input id="66" /> </Inputs> <Outputs> <Output id="959" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="1071" interactionType="Activate" points="1081 531, 2195 599, 1752 1564" position="2195 599" lineWidth="2.0"> <Inputs> <Input id="21" /> </Inputs> <Outputs> <Output id="1070" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="1072" interactionType="Activate" points="1098 624, 2052 692, 1747 1564" position="2052 692" lineWidth="2.0"> <Inputs> <Input id="54" /> </Inputs> <Outputs> <Output id="1070" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="1073" interactionType="Activate" points="1127 724, 2083 791, 1751 1564" position="2083 791" lineWidth="2.0"> <Inputs> <Input id="57" /> </Inputs> <Outputs> <Output id="1070" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="1074" interactionType="Activate" points="1135 937, 1910 962, 1744 1564" position="1910 962" lineWidth="2.0"> <Inputs> <Input id="60" /> </Inputs> <Outputs> <Output id="1070" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="1075" interactionType="Activate" points="1124 982, 1868 1000, 1742 1564" position="1868 1000" lineWidth="2.0"> <Inputs> <Input id="63" /> </Inputs> <Outputs> <Output id="1070" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="1076" interactionType="Activate" points="1109 1182, 1777 1322, 1739 1564" position="1777 1322" lineWidth="2.0"> <Inputs> <Input id="66" /> </Inputs> <Outputs> <Output id="1070" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="1077" interactionType="Activate" points="709 852, 791 1210, 1766 1343, 1738 1564" position="1278 1276" lineWidth="2.0"> <Inputs> <Input id="149" /> </Inputs> <Outputs> <Output id="1070" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="1078" interactionType="Activate" points="650 1062, 768 1253, 1746 1375, 1735 1564" position="1257 1314" lineWidth="2.0"> <Inputs> <Input id="152" /> </Inputs> <Outputs> <Output id="1070" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="1115" interactionType="Activate" points="1127 721, 2384 749, 2370 1561" position="2384 749" lineWidth="2.0"> <Inputs> <Input id="57" /> </Inputs> <Outputs> <Output id="1114" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="1116" interactionType="Activate" points="1135 936, 2360 953, 2369 1561" position="2360 953" lineWidth="2.0"> <Inputs> <Input id="60" /> </Inputs> <Outputs> <Output id="1114" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="1140" interactionType="Activate" points="1081 528, 2673 526, 2675 1406" position="2673 526" lineWidth="2.0"> <Inputs> <Input id="21" /> </Inputs> <Outputs> <Output id="1139" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="1153" interactionType="Activate" points="1081 528, 2879 500, 2875 1414" position="2879 500" lineWidth="2.0"> <Inputs> <Input id="21" /> </Inputs> <Outputs> <Output id="1152" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="1155" interactionType="Activate" points="1135 936, 2492 940, 2480 1404" position="2492 940" lineWidth="2.0"> <Inputs> <Input id="60" /> </Inputs> <Outputs> <Output id="1154" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="1589" reactomeId="9818937" points="997 467, 994 420, 1006 377" position="994 420" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="21" points="1025 515" /> <Input id="1590" points="951 466" /> </Inputs> <Outputs> <Output id="1591" /> </Outputs> <Properties> <displayName>MEN1 binds MLL1 complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1592" reactomeId="9821235" points="1209 309, 1265 315, 1347 305" position="1265 315" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1596" stoichiometry="2" points="1248 283" /> <Input id="1593" stoichiometry="2" points="1154 281" /> </Inputs> <Outputs> <Output id="1597" /> </Outputs> <Properties> <displayName>HCFC1, HCFC2 bind the MLL1:MEN1 complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="1594" points="1025 345, 1104 281" position="1064 313" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="1591" /> </Inputs> <Outputs> <Output id="1593" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="1595" points="1035 515, 1118 281" position="1076 398" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="21" /> </Inputs> <Outputs> <Output id="1593" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableReaction id="1598" reactomeId="9818954" points="1159 354, 1223 357, 1295 362" position="1223 357" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1599" points="1123 381" /> <Input id="1591" points="1080 357" /> </Inputs> <Outputs> <Output id="1600" /> </Outputs> <Properties> <displayName>PSIP1 binds MLL1 and MEN1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1601" reactomeId="9821368" points="1165 428, 1207 406, 1251 408" position="1207 406" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="21" points="1046 515" /> <Input id="1602" points="1434 473" /> </Inputs> <Outputs> <Output id="1603" /> </Outputs> <Properties> <displayName>AKAP8L binds MLL1 complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1604" reactomeId="9818682" points="968 588, 1014 578, 1078 578" position="1014 578" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="54" points="1022 607" /> <Input id="1590" points="931 483" /> </Inputs> <Outputs> <Output id="1605" /> </Outputs> <Properties> <displayName>MEN1 binds MLL2 complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1606" reactomeId="9821902" points="1257 581, 1283 579, 1326 582" position="1283 579" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1599" points="1119 412" /> <Input id="1605" points="1217 580" /> </Inputs> <Outputs> <Output id="1607" /> </Outputs> <Properties> <displayName>PSIP1 binds MEN1 associated with MLL2 complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1608" reactomeId="9821366" points="1429 700, 1459 694, 1505 697" position="1459 694" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="54" points="1098 630" /> <Input id="1602" points="1464 493" /> </Inputs> <Outputs> <Output id="1609" /> </Outputs> <Properties> <displayName>AKAP8L binds MLL2 complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1610" reactomeId="9821395" points="1045 843, 1085 851, 1110 839" position="1085 851" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1611" points="1022 840" /> <Input id="1612" points="1018 864" /> </Inputs> <Outputs> <Output id="1613" /> </Outputs> <Properties> <displayName>PAXIP1 binds PAGR1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1614" reactomeId="9821412" points="1219 797, 1257 795, 1320 798" position="1257 795" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="57" points="1098 735" /> <Input id="1615" points="1205 835" /> <Input id="1616" points="1258 837" /> <Input id="1613" points="1175 809" /> </Inputs> <Outputs> <Output id="1617" /> </Outputs> <Properties> <displayName>PAXIP1:PAGR1 complex, NCOA6 and KDM6A bind MLL3 complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1629" reactomeId="9821410" points="1179 899, 1253 897, 1333 884" position="1253 897" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1615" points="1196 863" /> <Input id="1616" points="1248 865" /> <Input id="60" points="1113 922" /> <Input id="1613" points="1148 839" /> </Inputs> <Outputs> <Output id="1630" /> </Outputs> <Properties> <displayName>PAXIP1:PAGR1 complex, NCOA6 and KDM6A bind MLL4 complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1631" reactomeId="9821475" points="1015 1046, 1081 1049, 1128 1050" position="1081 1049" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="63" points="1061 995" /> <Input id="1632" points="1006 1089" /> <Input id="1633" points="1078 1089" /> </Inputs> <Outputs> <Output id="1634" /> </Outputs> <Properties> <displayName>CXXC1 and WDR82 bind SET1A complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1635" reactomeId="9821486" points="1254 1047, 1357 1055, 1405 1054" position="1357 1055" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1634" points="1240 1048" /> <Input id="1636" points="1274 1033" /> </Inputs> <Outputs> <Output id="1637" /> </Outputs> <Properties> <displayName>HCFC1 binds SET1A complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1638" reactomeId="9821931" points="1281 1128, 1329 1124, 1409 1119" position="1329 1124" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1639" points="1290 1086" /> <Input id="1634" points="1206 1073" /> </Inputs> <Outputs> <Output id="1640" /> </Outputs> <Properties> <displayName>BOD1L1 binds SET1A complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1641" reactomeId="9821476" points="1201 1156, 1275 1149, 1364 1152" position="1275 1149" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1632" points="1034 1110" /> <Input id="1633" points="1116 1117" /> <Input id="66" points="1109 1166" /> </Inputs> <Outputs> <Output id="1642" /> </Outputs> <Properties> <displayName>CXXC1 and WDR82 bind SET1B complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1654" reactomeId="9821941" points="1612 1160, 1627 1178, 1674 1170" position="1627 1178" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1642" points="1561 1158" /> <Input id="1655" points="1703 1105" /> </Inputs> <Outputs> <Output id="1656" /> </Outputs> <Properties> <displayName>BOD1 binds SET1B complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1657" reactomeId="9828175" points="851 1539, 904 1545, 992 1553" position="904 1545" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1658" stoichiometry="2" points="708 1516" /> <Input id="1636" stoichiometry="2" points="1279 1033, 956 1494" /> <Input id="1659" stoichiometry="2" points="684 1587" /> <Input id="1660" stoichiometry="2" points="722 1446" /> <Input id="1661" stoichiometry="2" points="697 1544" /> <Input id="1662" points="715 1650" /> <Input id="1663" stoichiometry="2" points="704 1481" /> <Input id="1664" stoichiometry="2" points="706 1617" /> <Input id="7" stoichiometry="2" points="549 611, 246 636, 250 1596" /> </Inputs> <Outputs> <Output id="1665" /> </Outputs> <Properties> <displayName>Formation of the NSL complex</displayName> </Properties> </org.gk.render.RenderableReaction> </Edges> <Pathways /> </Process>
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No pathways have been reviewed or authored by Diagram of Formation of WDR5-containing histone-modifying complexes and Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome (9821921)
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