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Cytoplasmically dispersed NSP2 at some point associates w...
| Class:Id | Summation:9821641 |
|---|---|
| _displayName | Cytoplasmically dispersed NSP2 at some point associates w... |
| _timestamp | 2026-01-20 15:17:35 |
| created | [InstanceEdit:9821622] Stephan, Ralf, 2022-12-09 |
| literatureReference | [LiteratureReference:9821565] A Genetically Engineered Rotavirus NSP2 Phosphorylation Mutant Impaired in Viroplasm Formation and Replication Shows an Early Interaction between vNSP2 and Cellular Lipid Droplets [LiteratureReference:9822080] Recommendations for the classification of group A rotaviruses using all 11 genomic RNA segments |
| modified | [InstanceEdit:9824178] Stephan, Ralf, 2023-01-18 [InstanceEdit:9976886] Orlic-Milacic, Marija, 2025-12-15 [InstanceEdit:9979008] Orlic-Milacic, Marija, 2026-01-13 [InstanceEdit:9979647] Orlic-Milacic, Marija, 2026-01-20 |
| text | Cytoplasmically dispersed NSP2 at some point associates with NSP5 and lipid droplets (LD) to form LD-associated viroplasms. It was shown using the simian SA11 rotavirus strain that the first step in this process is the interaction of phosphorylated NSP2 with phosphorylated perilipin-1 (p-PLIN1) which is located on LDs (Criglar et al, 2020). Proteins from the simian rotavirus SA11 strains are commonly used in experiments resulting in general claims about rotavirus A strains. However, the SA11 NSP2 can be of genotype N2 or N5, while NSP2 from human strains can be of genotypes N1, N2, or N3 (Matthijnssens et al, 2008). Still, alignment of human Wa strain and SA11 NSP2 sequences show an overall 90% aa identity. |
| (summation) | [Reaction:9821586] p-S313-NSP2 octamer binds to p-PLIN1 on lipid droplets [Homo sapiens] |
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Cytoplasmically dispersed NSP2 at some point associates w... (9821641)
