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Cytosolic dispersed NSP2 is phosphorylated at S313 by cas...
| Class:Id | Summation:9821584 |
|---|---|
| _displayName | Cytosolic dispersed NSP2 is phosphorylated at S313 by cas... |
| _timestamp | 2026-01-20 15:17:36 |
| created | [InstanceEdit:9821583] Stephan, Ralf, 2022-12-09 |
| literatureReference | [LiteratureReference:9821594] Phosphorylation cascade regulates the formation and maturation of rotaviral replication factories [LiteratureReference:9822080] Recommendations for the classification of group A rotaviruses using all 11 genomic RNA segments |
| modified | [InstanceEdit:9821869] Stephan, Ralf, 2022-12-12 [InstanceEdit:9824177] Stephan, Ralf, 2023-01-18 [InstanceEdit:9976886] Orlic-Milacic, Marija, 2025-12-15 [InstanceEdit:9979647] Orlic-Milacic, Marija, 2026-01-20 |
| text | Cytosolic dispersed NSP2 is phosphorylated at S313 by casein kinase CK1alpha. There is evidence from the simian rotavirus strain SA11-4F that NSP2 gets hyperphosphorylated, either through autophosphorylation or by CK1alpha (Criglar et al, 2018). Proteins from the simian rotavirus SA11 strains are commonly used in experiments resulting in general claims about rotavirus A strains. However, the SA11 NSP2 can be of genotype N2 or N5, while NSP2 from human strains can be of genotypes N1, N2, or N3 (Matthijnssens et al, 2008). Still, alignment of human Wa strain and SA11 NSP2 sequences show the same S313 residue and an overall 90% aa identity. |
| (summation) | [Reaction:9821568] CK1α phosphorylates NSP2 octamer [Homo sapiens] |
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Cytosolic dispersed NSP2 is phosphorylated at S313 by cas... (9821584)
