Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person
VP7 proteins of rotavirus A (RV-A) trimerize in the prese...
| Class:Id | Summation:9821538 |
|---|---|
| _displayName | VP7 proteins of rotavirus A (RV-A) trimerize in the prese... |
| _timestamp | 2025-12-11 18:51:12 |
| created | [InstanceEdit:9821537] Stephan, Ralf, 2022-12-08 |
| literatureReference | [LiteratureReference:9821521] Purified recombinant rotavirus VP7 forms soluble, calcium-dependent trimers [LiteratureReference:9821522] Structure of rotavirus outer-layer protein VP7 bound with a neutralizing Fab [LiteratureReference:9822080] Recommendations for the classification of group A rotaviruses using all 11 genomic RNA segments |
| modified | [InstanceEdit:9821869] Stephan, Ralf, 2022-12-12 [InstanceEdit:9824173] Stephan, Ralf, 2023-01-17 [InstanceEdit:9976479] Orlic-Milacic, Marija, 2025-12-11 |
| text | VP7 proteins of rotavirus A (RV-A) trimerize in the presence of Ca2+, crystalizing into hexagonal plates that reproduce the hexagonal component of the icosahedral lattice of VP8 on triple-layered particles (TLPs) of RV-A (Dormitzer et al. 2000: simian RV-A strain RRV was used). The VP7 trimer is stabilized by two Ca2+ ions and four intramollecular disulfide bonds per subunit (Aoki et al. 2009: RRV was used). Proteins from the simian rotavirus RRV strain are commonly used in experiments resulting in general claims about rotavirus A strains. However, the simian VP7 proteins are of genotype G3, while VP7 from human strains can be of genotypes G1 through G12. VP7 from human strain D is of genotype G1 and has an overall amino acid identity with RRV VP7 of 81.3% (Matthijnssens et al. 2008). |
| (summation) | [Reaction:9821512] Glycosylated VP7 forms a trimer [Homo sapiens] |
| [Change default viewing format] | |
VP7 proteins of rotavirus A (RV-A) trimerize in the prese... (9821538)
