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Details on Person Expression of E2F1 target genes is stimulated by the complex of MLL1 and HCFC1

Class:Id	BlackBoxEvent:9821347
_displayName	Expression of E2F1 target genes is stimulated by the complex of MLL1 and HCFC1
_doRelease	FALSE
_timestamp	2022-12-02 15:51:55
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9821345] Orlic-Milacic, Marija, 2022-12-01
input	[CandidateSet:9821346] CCNA1 gene,E2F1 gene,RBL1 gene,(CDC25A gene) [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9821266] E2F activation of S phase promoters via association with HCF-1 and the MLL family of histone H3K4 methyltransferases [LiteratureReference:9821261] E2F1 mediates DNA damage and apoptosis through HCF-1 and the MLL family of histone methyltransferases
modified	[InstanceEdit:9821358] Orlic-Milacic, Marija, 2022-12-02
name	Expression of E2F1 target genes is stimulated by the complex of MLL1 and HCFC1
output	[CandidateSet:9821349] CCNA1,E2F1,RBL1,(CDC25A) [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:9821277] MLL1 complex trimethylates nucleosomes at promoters of E2F1 target genes [Homo sapiens] [Reaction:9821269] The complex of HCFC1 and MLL1 is recruited to E2F1 target promoters [Homo sapiens]
regulatedBy	[PositiveGeneExpressionRegulation:9821344] Positive gene expression regulation by 'MLL1 complex:HCFC1:E2F1:TFDP1,TFDP2:CCNA1 gene,E2F1 gene,RBL1 gene,(CDC25A gene) H3K4me3 chromatin [nucleoplasm]'
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9821351] R-HSA-9821347.1
summation	[Summation:9821356] MLL1 complex-mediated deposition of activating H3K4me3 marks...
(hasEvent)	[Pathway:9818561] Epigenetic regulation of gene expression by MLL1 complex [Homo sapiens]
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No pathways have been reviewed or authored by Expression of E2F1 target genes is stimulated by the complex of MLL1 and HCFC1 (9821347)