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Details on Person HCFC1 (also known as HCF1 or Host cell factor 1) directly bi...
| Class:Id | Summation:9821343 |
|---|---|
| _displayName | HCFC1 (also known as HCF1 or Host cell factor 1) directly bi... |
| _timestamp | 2022-12-01 15:12:13 |
| created | [InstanceEdit:9821345] Orlic-Milacic, Marija, 2022-12-01 |
| text | HCFC1 (also known as HCF1 or Host cell factor 1) directly binds to E2F1 and recruits the MLL1 histone methyltransferase complex to promoters of E2F1 target genes. Of the E2F1 target genes, activated at the G1/S phase transition, HCF1-mediated binding of the MLL1 complex was tested and confirmed for CCNA1 (cyclin A), E2F1, and RBL1 (p107) (Tyagi et al. 2007; Tyagi and Herr 2009), and reported but data not shown for CDC25A (Tyagi et al. 2007), so CDC25A gene is annotated as a candidate. HCFC1 was also reported to recruit the MLL1 complex to E2F1-regulated pro-apoptotic genes during oncogene-induced, E2F1-mediated apoptosis (Tyagi et al. 2009). |
| (summation) | [Reaction:9821269] The complex of HCFC1 and MLL1 is recruited to E2F1 target promoters [Homo sapiens] |
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No pathways have been reviewed or authored by HCFC1 (also known as HCF1 or Host cell factor 1) directly bi... (9821343)
