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Details on Person The MLL1 histone methyltransferase complex, recruited to pro...
| Class:Id | Summation:9821342 |
|---|---|
| _displayName | The MLL1 histone methyltransferase complex, recruited to pro... |
| _timestamp | 2022-12-01 15:12:13 |
| created | [InstanceEdit:9821345] Orlic-Milacic, Marija, 2022-12-01 |
| text | The MLL1 histone methyltransferase complex, recruited to promoters of E2F1 target genes by HCFC1 (also known as HCF1 or Host cell factor 1), trimethylates associated nucelosomes on histone H3, at lyine residue K5, creating the activating H3K4me3 epigenetic mark. Of the E2F1 target genes, activated at the G1/S phase transition, the MLL1 complex was tested and confirmed to deposit H3K4me3 mark on chromatin associated with CCNA1 (cyclin A), E2F1, and RBL1 (p107) genes (Tyagi et al. 2007; Tyagi and Herr 2009), and reported but data not shown for CDC25A gene (Tyagi et al. 2007), so CDC25A gene is annotated as a candidate. The HCFC1-recruited MLL1 complex has been reported to also deposit H3K4me3 marks on the chromatin of E2F1-regulated pro-apoptotic genes during oncogene-induced, E2F1-mediated apoptosis (Tyagi et al. 2009). |
| (summation) | [Reaction:9821277] MLL1 complex trimethylates nucleosomes at promoters of E2F1 target genes [Homo sapiens] |
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