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Details on Person MLL1 complex trimethylates nucleosomes at promoters of E2F1 target genes

Class:Id	Reaction:9821277
_displayName	MLL1 complex trimethylates nucleosomes at promoters of E2F1 target genes
_doRelease	FALSE
_timestamp	2022-12-01 15:12:27
catalystActivity	[CatalystActivity:9821328] histone H3K4 methyltransferase activity of MLL1 complex:HCFC1:E2F1:TFDP1,TFDP2:CCNA1 gene chromatin,E2F1 gene chromatin,RBL1 gene chromatin,(CDC25A gene chromatin) [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9821294] Orlic-Milacic, Marija, 2022-12-01
input	[CandidateSet:9821296] MLL1 complex:HCFC1:E2F1:TFDP1,TFDP2:CCNA1 gene chromatin,E2F1 gene chromatin,RBL1 gene chromatin,(CDC25A gene chromatin) [nucleoplasm] [Homo sapiens] [SimpleEntity:77087] AdoMet [nucleoplasm] [SimpleEntity:77087] AdoMet [nucleoplasm] [SimpleEntity:77087] AdoMet [nucleoplasm] [SimpleEntity:77087] AdoMet [nucleoplasm] [SimpleEntity:77087] AdoMet [nucleoplasm] [SimpleEntity:77087] AdoMet [nucleoplasm] [SimpleEntity:77087] AdoMet [nucleoplasm] [SimpleEntity:77087] AdoMet [nucleoplasm] [SimpleEntity:77087] AdoMet [nucleoplasm] [SimpleEntity:77087] AdoMet [nucleoplasm] [SimpleEntity:77087] AdoMet [nucleoplasm] [SimpleEntity:77087] AdoMet [nucleoplasm]
isChimeric	FALSE
literatureReference	[LiteratureReference:9821266] E2F activation of S phase promoters via association with HCF-1 and the MLL family of histone H3K4 methyltransferases [LiteratureReference:9821261] E2F1 mediates DNA damage and apoptosis through HCF-1 and the MLL family of histone methyltransferases
modified	[InstanceEdit:9821339] Orlic-Milacic, Marija, 2022-12-01 [InstanceEdit:9821353] Orlic-Milacic, Marija, 2022-12-01
name	MLL1 complex trimethylates nucleosomes at promoters of E2F1 target genes
output	[SimpleEntity:77502] AdoHcy [nucleoplasm] [SimpleEntity:77502] AdoHcy [nucleoplasm] [SimpleEntity:77502] AdoHcy [nucleoplasm] [SimpleEntity:77502] AdoHcy [nucleoplasm] [SimpleEntity:77502] AdoHcy [nucleoplasm] [SimpleEntity:77502] AdoHcy [nucleoplasm] [SimpleEntity:77502] AdoHcy [nucleoplasm] [SimpleEntity:77502] AdoHcy [nucleoplasm] [SimpleEntity:77502] AdoHcy [nucleoplasm] [SimpleEntity:77502] AdoHcy [nucleoplasm] [SimpleEntity:77502] AdoHcy [nucleoplasm] [SimpleEntity:77502] AdoHcy [nucleoplasm] [CandidateSet:9821331] MLL1 complex:HCFC1:E2F1:TFDP1,TFDP2:CCNA1 gene,E2F1 gene,RBL1 gene,(CDC25A gene) H3K4me3 chromatin [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:9821269] The complex of HCFC1 and MLL1 is recruited to E2F1 target promoters [Homo sapiens] [Reaction:9821235] HCFC1, HCFC2 bind the MLL1:MEN1 complex [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9821301] R-HSA-9821277.1
summation	[Summation:9821342] The MLL1 histone methyltransferase complex, recruited to pro...
(hasEvent)	[Pathway:9818561] Epigenetic regulation of gene expression by MLL1 complex [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9821347] Expression of E2F1 target genes is stimulated by the complex of MLL1 and HCFC1 [Homo sapiens]
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No pathways have been reviewed or authored by MLL1 complex trimethylates nucleosomes at promoters of E2F1 target genes (9821277)