Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person Both HCFC1 (also known as Host cell factor 1 or HCF1) and HC...
| Class:Id | Summation:9821247 |
|---|---|
| _displayName | Both HCFC1 (also known as Host cell factor 1 or HCF1) and HC... |
| _timestamp | 2023-02-10 19:19:13 |
| created | [InstanceEdit:9821246] Orlic-Milacic, Marija, 2022-11-30 |
| literatureReference | [LiteratureReference:9821230] Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression [LiteratureReference:9821258] The coactivator host cell factor-1 mediates Set1 and MLL1 H3K4 trimethylation at herpesvirus immediate early promoters for initiation of infection |
| modified | [InstanceEdit:9821259] Orlic-Milacic, Marija, 2022-11-30 [InstanceEdit:9821276] Orlic-Milacic, Marija, 2022-11-30 [InstanceEdit:9821908] Orlic-Milacic, Marija, 2022-12-14 [InstanceEdit:9823556] Orlic-Milacic, Marija, 2023-01-06 [InstanceEdit:9828150] Orlic-Milacic, Marija, 2023-02-10 |
| text | Both HCFC1 (also known as Host cell factor 1 or HCF1) and HCFC2 (also known as Host cell factor 2 or HCF2) can associate with the complex of MLL1 and MEN1 (Yokoyama et al. 2004; van Nuland et al. 2013) and pull down the components of the WRAD subcomplex (Yokoyama et al. 2004). The interaction occurs by binding of HCFC1 or HCFC2 to the N-terminal cleavage fragment of KMT2A (also known as MLL1 or MLL). HCFC2 appears to be the preferential binding partner of KMT2A. It is uncertain whether HCFC1 or HCFC2, when bound to the MLL1:MEN1 complex, associate with the HOXA9 gene promoter (Yokoyama et al. 2004). There is no evidence currently that MEN1 is required for binding of HCFC1 or HCFC2 to KMT2A. HCFC1-mediated recruitment of MLL1 is needed for H3K4 trimethylation and transcriptional activation of herpesvirus immediate early promoters at the onset of infection (Narayanan et al. 2007). |
| (summation) | [Reaction:9821235] HCFC1, HCFC2 bind the MLL1:MEN1 complex [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by Both HCFC1 (also known as Host cell factor 1 or HCF1) and HC... (9821247)
