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Details on Person Experiments in MA104 cells from rhesus monkey show that simi...

Class:IdSummation:9821161
_displayNameExperiments in MA104 cells from rhesus monkey show that simi...
_timestamp2025-11-14 12:45:03
created[InstanceEdit:9821175] Stephan, Ralf, 2022-11-29
literatureReference[LiteratureReference:9966208] Rotavirus viroplasm proteins interact with the cellular SUMOylation system: implications for viroplasm-like structure formation
[LiteratureReference:9821179] In situ Structure of Rotavirus VP1 RNA-Dependent RNA Polymerase
[LiteratureReference:9821132] Mechanism for coordinated RNA packaging and genome replication by rotavirus polymerase VP1
[LiteratureReference:9821254] Localization of rotavirus antigens in infected cells by ultrastructural immunocytochemistry
[LiteratureReference:9822080] Recommendations for the classification of group A rotaviruses using all 11 genomic RNA segments
modified[InstanceEdit:9821537] Stephan, Ralf, 2022-12-08
[InstanceEdit:9821869] Stephan, Ralf, 2022-12-12
[InstanceEdit:9823638] Stephan, Ralf, 2023-01-07
[InstanceEdit:9827796] Stephan, Ralf, 2023-02-06
[InstanceEdit:9966212] Orlic-Milacic, Marija, 2025-09-11
[InstanceEdit:9973159] Orlic-Milacic, Marija, 2025-11-14
textExperiments in MA104 cells from rhesus monkey show that simian rotavirus SA11 VP2 localizes to the cytosol (Petrie et al, 1982). It probably decamerizes immediately after translation. VP2 decamers are part of basic virion assembly units and consist of five units of VP2A and VP2B, respectively, the two being different conformations (Lu et al. 2008; Jenni et al. 2019).

Proteins from the simian rotavirus A (RV-A) SA11 and RRV strains are commonly used in experiments resulting in general claims about rotavirus A strains (Petrie et al. 1982; Lu et al. 2008; Jenni et al. 2019). However, the simian VP2 proteins are of genotype C3 and C5, while VP2 from human strains can be of genotype C1 or C2 (Matthijnssens et al, 2008). VP2 may undergo SUMOylation, which could positively regulate RV-A replication (Campagna et al. 2013).
(summation)[BlackBoxEvent:9821148] VP2 forms a decamer [Homo sapiens]
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