Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person Transcription factors CDX4 and MEN1 are both needed for HOXA...

Class:IdSummation:9821080
_displayNameTranscription factors CDX4 and MEN1 are both needed for HOXA...
_timestamp2022-11-29 20:10:50
created[InstanceEdit:9821085] Orlic-Milacic, Marija, 2022-11-29
literatureReference[LiteratureReference:9821081] Cdx4 and menin co-regulate Hoxa9 expression in hematopoietic cells
modified[InstanceEdit:9821214] Orlic-Milacic, Marija, 2022-11-29
textTranscription factors CDX4 and MEN1 are both needed for HOXA9 expression and normal hematopoiesis. By chromatin immunoprecipitation (ChIP) in mouse bone marrow cell lines transformed by the overexpression of the human leukemia-derived KMT2A (MLL1) fusion protein MLL-AF9, CDX4 and MEN1 bind to the same regulatory region at the HOXA9 promoter in vivo, and MEN1 is needed for access of CDX4 to the HOXA9 promoter, likely through the establishment of H3K4me3 marks of active chromatin by the complex of MLL1 and MEN1 (Yan et al. 2006). Human CDX4 was shown to bind to promoter elements of the human HOXA10 gene, using pro-myeloid human cancer cell line U937 (Bei et al. 2011).
(summation)[Reaction:9821018] CDX4 binds to HOXA9,HOXA10 gene promoters [Homo sapiens]
[Change default viewing format]
No pathways have been reviewed or authored by Transcription factors CDX4 and MEN1 are both needed for HOXA... (9821080)
Follow Reactome