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Details on Person Expression of HOXA9 gene, (HOXA10 gene) is positively regulated by CDX4

Class:Id	BlackBoxEvent:9821070
_displayName	Expression of HOXA9 gene, (HOXA10 gene) is positively regulated by CDX4
_doRelease	FALSE
_timestamp	2022-11-29 20:10:49
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9821068] Orlic-Milacic, Marija, 2022-11-29
inferredFrom	[BlackBoxEvent:9821113] Expression of Hoxa9 gene is positively regulated by Cdx4 [Homo sapiens]
input	[CandidateSet:9821069] HOXA9 gene, (HOXA10 gene) [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9821120] Cooperation between AlphavBeta3 integrin and the fibroblast growth factor receptor enhances proliferation of Hox-overexpressing acute myeloid leukemia cells [LiteratureReference:9821209] HoxA10 activates CDX4 transcription and Cdx4 activates HOXA10 transcription in myeloid cells
modified	[InstanceEdit:9821089] Orlic-Milacic, Marija, 2022-11-29 [InstanceEdit:9821117] Orlic-Milacic, Marija, 2022-11-29 [InstanceEdit:9821125] Orlic-Milacic, Marija, 2022-11-29 [InstanceEdit:9821214] Orlic-Milacic, Marija, 2022-11-29
name	Expression of HOXA9 gene, (HOXA10 gene) is positively regulated by CDX4
output	[CandidateSet:9821071] HOXA9, (HOXA10) [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:9821018] CDX4 binds to HOXA9,HOXA10 gene promoters [Homo sapiens] [Reaction:9819024] MLL1 complex bound to MEN1 trimethylates nucleosomes at MLL1 target gene loci [Homo sapiens]
regulatedBy	[PositiveGeneExpressionRegulation:9821067] Positive gene expression regulation by 'CDX4:MLL1 complex:MEN1:HOXA9 gene,(HOXA10 gene) H3K4me3 chromatin [nucleoplasm]'
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9821073] R-HSA-9821070.1
summation	[Summation:9821087] Transcription factors CDX4 and MEN1 are both needed for HOXA...
(hasEvent)	[Pathway:9818561] Epigenetic regulation of gene expression by MLL1 complex [Homo sapiens]
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No pathways have been reviewed or authored by Expression of HOXA9 gene, (HOXA10 gene) is positively regulated by CDX4 (9821070)