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Details on Person Maternal transcripts are transcribed from the maternal genom...
| Class:Id | Summation:9820987 |
|---|---|
| _displayName | Maternal transcripts are transcribed from the maternal genom... |
| _timestamp | 2023-01-05 02:40:19 |
| created | [InstanceEdit:9820982] May, Bruce, 2022-11-27 |
| modified | [InstanceEdit:9821723] May, Bruce, 2022-12-10 [InstanceEdit:9823023] May, Bruce, 2023-01-03 [InstanceEdit:9823275] May, Bruce, 2023-01-05 |
| text | Maternal transcripts are transcribed from the maternal genome and accumulate in the oocyte during oogenesis. A subset of these maternal transcripts is degraded during later development of the unfertilized oocyte and after fertilization of the oocyte. Maternal decay of maternal transcripts (M-decay, reviewed in Jian and Fan 2022) refers to the degradation of maternal transcripts by maternally provided factors such as ZFP36L2 (inferred from the mouse homolog in Chousal et al. 2018, Sha et al. 2018), BTG4 (inferred from the mouse homolog in Liu et al. 2016, Yu et al. 2016, Pasternak et al. 2016, Zhao et al. 2020), and AGO2 (inferred from the mouse homolog in Zhang et al. 2020). ZFP36L2 acting before fertilization and BTG4 acting after fertilization recruit the CCR4-NOT deadenylation complex to the mRNA to initiate degradation. AGO2 is primed with endogenous small interfering RNAs (endosiRNAs) produced from double-stranded RNAs that originate from specific loci. The resulting AGO2:endosiRNA complexes bind and hydrolyze complementary maternal mRNAs. Similar patterns of mRNA decay are observed in human and mouse zygotes (Sha et al. 2020). |
| (summation) | [Pathway:9820841] M-decay: degradation of maternal mRNAs by maternally stored factors [Homo sapiens] |
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No pathways have been reviewed or authored by Maternal transcripts are transcribed from the maternal genom... (9820987)
