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Details on Person Before and during zygotic genome activation, AGO2 bound to a...
| Class:Id | Summation:9820834 |
|---|---|
| _displayName | Before and during zygotic genome activation, AGO2 bound to a... |
| _timestamp | 2023-01-05 02:38:50 |
| created | [InstanceEdit:9820878] May, Bruce, 2022-11-21 |
| literatureReference | [LiteratureReference:9820897] Argonaute 2 is a key regulator of maternal mRNA degradation in mouse early embryos |
| modified | [InstanceEdit:9821723] May, Bruce, 2022-12-10 [InstanceEdit:9823275] May, Bruce, 2023-01-05 |
| text | Before and during zygotic genome activation, AGO2 bound to an endogenous small interfering RNA (endosiRNA) derived from transcripts of a maternally expressed gene (AGO2:endosiRNA) hydrolyzes the cognate maternal mRNA at the site of complementarity with the endosiRNA (inferred from mouse homologs). In mouse early embryos, Ago2 is involved in the decay of over half of the maternal mRNAs (Zhang et al. 2020). |
| (summation) | [Reaction:9820842] AGO2:endosiRNA hydrolyzes maternal mRNA in the zygote [Homo sapiens] |
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No pathways have been reviewed or authored by Before and during zygotic genome activation, AGO2 bound to a... (9820834)
