Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:Q96H96-6 COQ2
| Class:Id | ReferenceIsoform:9819446 |
|---|---|
| _chainChangeLog | transit peptide:1-34 for 9819446 added on Fri November 4 2022;chain:35-371 for 9819446 added on Fri November 4 2022 |
| _displayName | UniProt:Q96H96-6 COQ2 |
| _timestamp | 2025-02-21 19:57:44 |
| chain | transit peptide:1-34 chain:35-371 |
| checksum | 8BCE473A1D0C60CB |
| comment | FUNCTION Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis (PubMed:15153069, PubMed:16400613, PubMed:17374725, PubMed:20526342). Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl donor (such as all-trans-decaprenyl diphosphate) (PubMed:15153069, PubMed:16400613, PubMed:17374725, PubMed:20526342). The length of the polyprenyl side chain varies depending on the species, in humans, the side chain is comprised of 10 isoprenyls (decaprenyl) producing CoQ10 (also known as ubiquinone), whereas rodents predominantly generate CoQ9 (PubMed:15153069, PubMed:16400613). However, this specificity is not complete, human tissues have low amounts of CoQ9 and rodent organs contain some CoQ10 (PubMed:15153069). Plays a central role in the biosynthesis of CoQ10 (PubMed:15153069, PubMed:16400613, PubMed:17374725). CoQ10 is a vital molecule that transports electrons from mitochondrial respiratory chain complexes (PubMed:16400613, PubMed:17374725, PubMed:27493029). CoQs also function as cofactors for uncoupling protein and play a role as regulators of the extracellularly-induced ceramide-dependent apoptotic pathway (PubMed:16400613, PubMed:17374725). Regulates mitochondrial permeability transition pore (mPTP) opening and ROS production (pivotal events in cell death) in a tissue specific manner (By similarity).CATALYTIC ACTIVITY an all-trans-polyprenyl diphosphate + 4-hydroxybenzoate = a 4-hydroxy-3-(all-trans-polyprenyl)benzoate + diphosphateCATALYTIC ACTIVITY all-trans-decaprenyl diphosphate + 4-hydroxybenzoate = 4-hydroxy-3-(all-trans-decaprenyl)benzoate + diphosphateCATALYTIC ACTIVITY all-trans-nonaprenyl diphosphate + 4-hydroxybenzoate = 4-hydroxy-3-(all-trans-nonaprenyl)benzoate + diphosphateCOFACTOR Cofactor biosynthesis; ubiquinone biosynthesis.SUBCELLULAR LOCATION Widely expressed. Present in all of the tissues tested. Expressed at higher level in skeletal muscle, adrenal glands and the heart.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE Disease susceptibility is associated with variants affecting the gene represented in this entry.MISCELLANEOUS Potential minor and functional isoform produced by alternative initiation.MISCELLANEOUS Potential minor and functional isoform produced by alternative initiation.MISCELLANEOUS Potential minor and functional isoform produced by alternative initiation.SIMILARITY Belongs to the UbiA prenyltransferase family.SEQUENCE CAUTION Extended N-terminus. |
| created | [InstanceEdit:9819394] Weiser, Joel |
| description | recommendedName: fullName evidence="2"4-hydroxybenzoate polyprenyltransferase, mitochondrial shortName evidence="2"4-HB polyprenyltransferase ecNumber evidence="3 5 6"2.5.1.39 alternativeName: fullName evidence="15"4-hydroxybenzoate decaprenyltransferase alternativeName: COQ2 homolog shortName evidence="15"hCOQ2 alternativeName: fullName evidence="16"Para-hydroxybenzoate--polyprenyltransferase shortName evidence="2"PHB:PPT shortName evidence="2"PHB:polyprenyltransferase |
| geneName | COQ2 CL640 |
| identifier | Q96H96 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | Alternative initiation Alternative splicing Disease variant Isoprene biosynthesis Membrane Mitochondrion Mitochondrion inner membrane Neurodegeneration Parkinsonism Primary mitochondrial disease Proteomics identification Reference proteome Transferase Transit peptide Transmembrane Transmembrane helix Ubiquinone biosynthesis |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | COQ2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8987754] ENSEMBL:ENSG00000173085 COQ2 [Homo sapiens] |
| secondaryIdentifier | COQ2_HUMAN A0A1D8H0A6 O95331 Q1JQ78 Q684R2 |
| sequenceLength | 371 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | Q96H96-6 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q96H96-6 COQ2 (9819446)
