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Details on Person The complex of MLL1 and MEN1 binds target gene loci

Class:Id	Reaction:9819008
_displayName	The complex of MLL1 and MEN1 binds target gene loci
_doRelease	FALSE
_timestamp	2022-10-31 19:02:46
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9819009] Orlic-Milacic, Marija, 2022-10-31
input	[Complex:9818943] MLL1 complex:MEN1 [nucleoplasm] [Homo sapiens] [CandidateSet:9819026] HOXC8 gene, (HOXC6 gene), HOXA7 gene, HOXA9 gene, HOXA10 gene chromatin [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:5244699] Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus [LiteratureReference:9818939] The same pocket in menin binds both MLL and JUND but has opposite effects on transcription
modified	[InstanceEdit:9819020] Orlic-Milacic, Marija, 2022-10-31 [InstanceEdit:9819031] Orlic-Milacic, Marija, 2022-10-31 [InstanceEdit:9819048] Orlic-Milacic, Marija, 2022-10-31 [InstanceEdit:9819053] Orlic-Milacic, Marija, 2022-10-31
name	The complex of MLL1 and MEN1 binds target gene loci
output	[CandidateSet:9819006] MLL1 complex:MEN1:HOXC8 gene, (HOXC6 gene), HOXA7 gene, HOXA9 gene, HOXA10 gene chromatin [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:9818937] MEN1 binds MLL1 complex [Homo sapiens] [Reaction:9675026] Formation of the MLL1 complex [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9819011] R-HSA-9819008.1
summation	[Summation:9819017] Based on studies in mice, expression of HOXC8 gene is depend...
(hasEvent)	[Pathway:9818561] Epigenetic regulation of gene expression by MLL1 complex [Homo sapiens]
(precedingEvent)	[Reaction:9819024] MLL1 complex bound to MEN1 trimethylates nucleosomes at MLL1 target gene loci [Homo sapiens]
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No pathways have been reviewed or authored by The complex of MLL1 and MEN1 binds target gene loci (9819008)