Query author contributions in Reactome
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Details on Person By chromatin immunoprecipitation (ChIP), KMT2A (also known a...
| Class:Id | Summation:9819001 |
|---|---|
| _displayName | By chromatin immunoprecipitation (ChIP), KMT2A (also known a... |
| _timestamp | 2022-11-29 00:29:28 |
| created | [InstanceEdit:9819002] Orlic-Milacic, Marija, 2022-10-31 |
| modified | [InstanceEdit:9819004] Orlic-Milacic, Marija, 2022-10-31 [InstanceEdit:9819005] Orlic-Milacic, Marija, 2022-10-31 [InstanceEdit:9819140] Orlic-Milacic, Marija, 2022-11-01 [InstanceEdit:9819303] Orlic-Milacic, Marija, 2022-11-02 [InstanceEdit:9821020] Orlic-Milacic, Marija, 2022-11-29 |
| text | By chromatin immunoprecipitation (ChIP), KMT2A (also known as MLL1 or MLL), MEN1 (menin) and PSIP1 (LEDGF) were shown to co-occupy MLL1 target gene loci HOXA7, HOXA9, MEIS1, CDKN1B and CDKN2C. Binding of PSIP1 to KMT2A and MEN1 is needed for upregulation of HOXA9 gene expression (Yokoyama and Cleary 2008). Previously, the complex of KMT2A and MEN1 was shown to occupy HOXA7, HOXA9 and HOXA10 gene loci (Yokoyama et al. 2005). Exogenous expression of human leukemia-derived KMT2A fusion proteins in mouse myeloid progenitor cells results at increased binding of MEN1 to the HOXA9 gene locus (Caslini et al. 2009). |
| (summation) | [Reaction:9818984] The complex of MLL1, MEN1 and PSIP1 binds target gene loci [Homo sapiens] |
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No pathways have been reviewed or authored by By chromatin immunoprecipitation (ChIP), KMT2A (also known a... (9819001)
