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Details on Person PSIP1 (also known as LEDGF) conjointly binds to KMT2A (also ...
| Class:Id | Summation:9818986 |
|---|---|
| _displayName | PSIP1 (also known as LEDGF) conjointly binds to KMT2A (also ... |
| _timestamp | 2023-02-10 19:24:16 |
| created | [InstanceEdit:9818987] Orlic-Milacic, Marija, 2022-10-31 |
| modified | [InstanceEdit:9819005] Orlic-Milacic, Marija, 2022-10-31 [InstanceEdit:9819136] Orlic-Milacic, Marija, 2022-11-01 [InstanceEdit:9821905] Orlic-Milacic, Marija, 2022-12-14 [InstanceEdit:9821909] Orlic-Milacic, Marija, 2022-12-14 [InstanceEdit:9823557] Orlic-Milacic, Marija, 2023-01-06 [InstanceEdit:9828152] Orlic-Milacic, Marija, 2023-02-10 |
| text | PSIP1 (also known as LEDGF) conjointly binds to KMT2A (also known as MLL1 or MLL) and MEN1 (menin) (Yokoyama and Cleary 2008; Huang et al. 2012). The LEDGF-binding motif (LBM) in the N-terminus of KMT2A is missing in KMT2B (Huang et al. 2012), but the interaction of PSIP1 with MEN1-bound MLL2 complexes has been reported (van Nuland et al. 2013). Based on quantitative studies in HeLa cells, all PSIP1-containing MLL1/MLL2 complexes contain MEN1, but only about 25% of MEN1-containing MLL1/MLL2 complexes contain PSIP1 (van Nuland et al. 2013). HCFC2 has been found to be co-immunoprecipitated with PSIP1, so it is possible that a portion of MLL1 complexes with MEN1 and PSIP1 also include HCFC1 or HCFC2 (van Nuland et al. 2013). |
| (summation) | [Reaction:9818954] PSIP1 binds MLL1 and MEN1 [Homo sapiens] |
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No pathways have been reviewed or authored by PSIP1 (also known as LEDGF) conjointly binds to KMT2A (also ... (9818986)
