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Details on Person MEN1 (also known as Menin) associates with the MLL1 complex ...
| Class:Id | Summation:9818934 |
|---|---|
| _displayName | MEN1 (also known as Menin) associates with the MLL1 complex ... |
| _timestamp | 2023-02-13 16:42:45 |
| created | [InstanceEdit:9818948] Orlic-Milacic, Marija, 2022-10-28 |
| modified | [InstanceEdit:9819163] Orlic-Milacic, Marija, 2022-11-01 [InstanceEdit:9819302] Orlic-Milacic, Marija, 2022-11-02 [InstanceEdit:9821898] Orlic-Milacic, Marija, 2022-12-14 [InstanceEdit:9823556] Orlic-Milacic, Marija, 2023-01-06 [InstanceEdit:9828149] Orlic-Milacic, Marija, 2023-02-10 [InstanceEdit:9828344] Orlic-Milacic, Marija, 2023-02-13 |
| text | MEN1 (also known as Menin) associates with the MLL1 complex by binding to the N-terminal region of KMT2A (also known as MLL1 or MLL) (Yokoyama et al. 2005; Caslini et al. 2007; Grembecka et al. 2010; Huang et al. 2012). The N-terminal region of KMT2A contains two putative menin-binding motifs (MBMs) (Grembecka et al. 2010), with residues 6–25 of KMT2A being necessary and sufficient for binding to MEN1 (Huang et al. 2012: recombinant human MEN1 and KMT2A were used). Presence of MEN1-binding motif is necessary for leukemic transformation of mouse myeloid progenitor cells by human leukemia-derived KMT2A fusion proteins and induction of MLL1 target genes HOXA9 and MEIS1 (Caslini et al. 2009). Based on quantitative studies in HeLa cells, MEN1 has 4- to 5-fold-lower abundance in MLL1/MLL2 complexes than KMT2A/KMT2B, indicating that not all MLL1/2 complexes contain MEN1 (van Nuland et al. 2013). |
| (summation) | [Reaction:9818937] MEN1 binds MLL1 complex [Homo sapiens] |
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No pathways have been reviewed or authored by MEN1 (also known as Menin) associates with the MLL1 complex ... (9818934)
