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Details on Person MEN1 (also known as Menin), a tumor suppressor protein mutat...
| Class:Id | Summation:9818684 |
|---|---|
| _displayName | MEN1 (also known as Menin), a tumor suppressor protein mutat... |
| _timestamp | 2023-02-10 19:27:24 |
| created | [InstanceEdit:9818685] Orlic-Milacic, Marija, 2022-10-20 |
| modified | [InstanceEdit:9818951] Orlic-Milacic, Marija, 2022-10-28 [InstanceEdit:9821362] Orlic-Milacic, Marija, 2022-12-02 [InstanceEdit:9821898] Orlic-Milacic, Marija, 2022-12-14 [InstanceEdit:9823559] Orlic-Milacic, Marija, 2023-01-06 [InstanceEdit:9828154] Orlic-Milacic, Marija, 2023-02-10 |
| text | MEN1 (also known as Menin), a tumor suppressor protein mutated in multiple type I endocrine neoplasia, binds to the MLL2 complex. The endogenous complex of MEN1 and MLL2 was co-immunoprecipitated from human cervical carcinoma cell line HeLa and human embryonic kidney cell line HEK293 (Hughes et al. 2004; Jiang et al. 2013: recombinant human KMT2B was used for co-immunoprecipitation from HEK293 cells). The KMT2B (also known as MLL2), similar to the closely related KMT2A (also known as MLL1 or MLL), contains the menin-binding motif (MBM) at its N-terminus, spanning amino acid residues 16–35 (Huang et al. 2012). Based on quantitative studies in HeLa cells, MEN1 has 4- to 5-fold-lower abundance in MLL1/MLL2 complexes than KMT2A/KMT2B, indicating that not all MLL1/2 complexes contain menin (van Nuland et al. 2013). Huang et al. 2012: recombinant human MEN1 and KMT2B were used. |
| (summation) | [Reaction:9818682] MEN1 binds MLL2 complex [Homo sapiens] |
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