Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person Diagram of Epigenetic regulation of gene expression by MLL1 complex
| Class:Id | PathwayDiagram:9818679 |
|---|---|
| _displayName | Diagram of Epigenetic regulation of gene expression by MLL1 complex |
| _timestamp | 2023-02-07 15:14:07 |
| created | [InstanceEdit:9818680] Orlic-Milacic, Marija, 2022-10-20 |
| height | 1184 |
| modified | [InstanceEdit:9821929] Orlic-Milacic, Marija, 2022-12-15 [InstanceEdit:9821937] Orlic-Milacic, Marija, 2022-12-15 [InstanceEdit:9822170] Orlic-Milacic, Marija, 2022-12-19 [InstanceEdit:9827844] Orlic-Milacic, Marija, 2023-02-07 |
| representedPathway | [Pathway:9818561] Epigenetic regulation of gene expression by MLL1 complex [Homo sapiens] |
| storedATXML | <?xml version="1.0" encoding="UTF-8"?> <Process nextId="3046" reactomeDiagramId="9818679"> <Properties> <displayName>Diagram of Epigenetic regulation of gene expression by MLL1 complex</displayName> </Properties> <Nodes> <org.gk.render.RenderableComplex id="25" reactomeId="9675218" position="379 620" bounds="333 609 92 22" textPosition="333 610" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>MLL1 complex</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="138" reactomeId="2186626" position="435 788" bounds="414 777 42 22" textPosition="414 777"> <Properties> <displayName>MEN1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="590" reactomeId="9818943" position="592 664" bounds="543 646 99 36" textPosition="545 647" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>MLL1 complex:MEN1</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="722" reactomeId="3008841" position="531 569" bounds="511 558 41 22" textPosition="512 558"> <Properties> <displayName>PSIP1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="723" reactomeId="9818952" position="721 536" bounds="672 518 99 36" textPosition="674 519" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>MLL1 complex:MEN1:PSIP1</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="776" reactomeId="9818985" position="973 531" bounds="911 506 124 50" textPosition="911 507" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>MLL1 complex:MEN1:PSIP1:Target genes chromatin</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntitySet id="994" reactomeId="9819010" position="969 455" bounds="922 418 94 75" textPosition="920 417"> <Properties> <displayName>HOXC8 gene, (HOXC6 gene), HOXA7 gene, HOXA9 gene, HOXA10 gene</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableChemical id="1175" reactomeId="77502" position="679 340" bounds="649 325 61 30" textPosition="653 329" /> <org.gk.render.RenderableChemical id="1177" reactomeId="77087" position="543 374" bounds="513 359 61 30" textPosition="517 363" /> <org.gk.render.RenderableEntitySet id="1237" reactomeId="9819042" position="991 343" bounds="957 303 68 81" textPosition="958 305"> <Properties> <displayName>HOXC8, (HOXC6), HOXA7, HOXA9, HOXA10</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="1529" reactomeId="9819138" position="772 473" bounds="699 456 146 35" textPosition="701 456" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>MLL1, MEN1. PSIP1 target genes chromatin</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="1616" reactomeId="9819142" position="1290 521" bounds="1213 498 155 47" textPosition="1224 496" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>MLL1 complex:MEN1:PSIP1:target genes H3K4me3 chromatin</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="1618" reactomeId="77502" position="1213 600" bounds="1183 585 61 30" textPosition="1187 589" /> <org.gk.render.RenderableChemical id="1620" reactomeId="77087" position="1064 600" bounds="1034 585 61 30" textPosition="1038 589" /> <org.gk.render.RenderableEntitySet id="1798" reactomeId="9818988" position="1154 388" bounds="1093 366 123 45" textPosition="1093 371"> <Properties> <displayName>MLL1, MEN1. PSIP1 target genes</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="1800" reactomeId="9819148" position="1383 379" bounds="1315 354 137 51" textPosition="1318 355"> <Properties> <displayName>Proteins encoded by MLL1, MEN1, PSIP1 target genes</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="2275" reactomeId="9819026" position="314 484" bounds="263 437 102 95" textPosition="265 439" bgColor="204 255 255"> <Properties> <displayName>HOXC8 gene, (HOXC6 gene), HOXA7 gene, HOXA9 gene, HOXA10 gene chromatin</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="2369" reactomeId="9819006" position="528 490" bounds="465 438 127 104" textPosition="465 438" bgColor="204 255 255"> <Properties> <displayName>MLL1 complex:MEN1:HOXC8 gene, (HOXC6 gene), HOXA7 gene, HOXA9 gene, HOXA10 gene chromatin</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="2436" reactomeId="9819034" position="800 373" bounds="737 313 127 121" textPosition="737 314" bgColor="204 255 255"> <Properties> <displayName>MLL1 complex:MEN1:HOXC8 gene, (HOXC6 gene), HOXA7 gene, HOXA9 gene, HOXA10 gene H3K4me3 chromatin</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="2480" reactomeId="9821058" position="744 251" bounds="620 232 248 39" textPosition="633 234" bgColor="204 255 255" fgColor="0 0 0" lineColor="0 0 0" lineWidth="1.0"> <Properties> <displayName>MLL1 complex:MEN1:HOXA9 gene, (HOXA10 gene) H3K4me3 chromatin</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableProtein id="2482" reactomeId="5624405" position="985 232" bounds="957 221 57 22" textPosition="965 221"> <Properties> <displayName>CDX4</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableEntitySet id="2516" reactomeId="9821059" position="1219 248" bounds="1091 227 257 43" textPosition="1095 231" bgColor="204 255 255"> <Properties> <displayName>CDX4:MLL1 complex:MEN1:HOXA9 gene,(HOXA10 gene) H3K4me3 chromatin</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="2594" reactomeId="9821069" position="1243 312" bounds="1191 294 105 36" textPosition="1194 294"> <Properties> <displayName>HOXA9 gene, (HOXA10 gene)</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="2598" reactomeId="9821071" position="1524 313" bounds="1489 297 70 33" textPosition="1491 296"> <Properties> <displayName>HOXA9, (HOXA10)</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="2603" reactomeId="9821240" position="693 673" bounds="665 656 57 34" textPosition="668 656"> <Properties> <displayName>HCFC1,HCFC2</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="2747" reactomeId="9821264" position="743 601" bounds="620 586 246 30" textPosition="635 590" bgColor="204 255 255" fgColor="0 0 0" lineColor="0 0 0" lineWidth="1.0"> <Properties> <displayName>MLL1 complex,MLL1 complex:MEN1</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="2786" reactomeId="9821241" position="975 664" bounds="907 637 137 54" textPosition="911 639" bgColor="204 255 255"> <Properties> <displayName>MLL1 complex,MLL1 complex:MEN1:HCFC1,HCFC2</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="2868" reactomeId="9821279" position="1027 726" bounds="893 707 268 38" textPosition="893 708" bgColor="204 255 255" fgColor="0 0 0" lineColor="0 0 0" lineWidth="1.0"> <Properties> <displayName>E2F1:TFDP1,TFDP2:CCNA1 gene,E2F1 gene,RBL1 gene,(CDC25A gene) chromatin</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="2869" reactomeId="9821263" position="1159 651" bounds="1088 639 142 25" textPosition="1092 643" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>MLL1 complex:HCFC1</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntitySet id="2870" reactomeId="9821296" position="1440 711" bounds="1292 685 296 53" textPosition="1290 687" bgColor="204 255 255" fgColor="0 0 0" lineColor="0 0 0" lineWidth="1.0"> <Properties> <displayName>MLL1 complex:HCFC1:E2F1:TFDP1,TFDP2:CCNA1 gene chromatin,E2F1 gene chromatin,RBL1 gene chromatin,(CDC25A gene chromatin)</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="2873" reactomeId="9821331" position="1992 704" bounds="1909 666 167 77" textPosition="1908 666" bgColor="204 255 255" fgColor="0 0 0" lineColor="0 0 0" lineWidth="1.0"> <Properties> <displayName>MLL1 complex:HCFC1:E2F1:TFDP1,TFDP2:CCNA1 gene,E2F1 gene,RBL1 gene,(CDC25A gene) H3K4me3 chromatin</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableChemical id="2875" reactomeId="77087" position="1665 795" bounds="1635 780 61 30" textPosition="1639 784"> <Properties> <displayName>AdoMet</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="2877" reactomeId="77502" position="1837 780" bounds="1807 765 61 30" textPosition="1811 769"> <Properties> <displayName>AdoHcy</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableEntitySet id="2879" reactomeId="9821346" position="1828 563" bounds="1778 523 101 81" textPosition="1780 532"> <Properties> <displayName>CCNA1 gene,E2F1 gene,RBL1 gene,(CDC25A gene)</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="2880" reactomeId="9821349" position="2153 552" bounds="2120 514 67 77" textPosition="2121 521"> <Properties> <displayName>CCNA1,E2F1,RBL1,(CDC25A)</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableProtein id="3031" reactomeId="9821364" position="267 616" bounds="240 605 54 22" textPosition="240 605"> <Properties> <displayName>AKAP8L</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="3032" reactomeId="9821367" position="335 754" bounds="287 736 96 36" textPosition="287 737" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>MLL1 complex:AKAP8L</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableCompartment id="3033" reactomeId="7660" position="1199 575" bounds="198 173 2002 804" textPosition="231 925" bgColor="250 240 240" lineColor="255 153 102" insets="202 183 1990 784"> <Components> <Component id="25" /> <Component id="138" /> <Component id="590" /> <Component id="722" /> <Component id="723" /> <Component id="776" /> <Component id="994" /> <Component id="1175" /> <Component id="1177" /> <Component id="1237" /> <Component id="1529" /> <Component id="1616" /> <Component id="1618" /> <Component id="1620" /> <Component id="1798" /> <Component id="1800" /> <Component id="2275" /> <Component id="2369" /> <Component id="2436" /> <Component id="2480" /> <Component id="2482" /> <Component id="2516" /> <Component id="2594" /> <Component id="2598" /> <Component id="2603" /> <Component id="2747" /> <Component id="2786" /> <Component id="2868" /> <Component id="2869" /> <Component id="2870" /> <Component id="2873" /> <Component id="2875" /> <Component id="2877" /> <Component id="2879" /> <Component id="2880" /> <Component id="3031" /> <Component id="3032" /> <Component id="589" /> <Component id="721" /> <Component id="774" /> <Component id="993" /> <Component id="1172" /> <Component id="1236" /> <Component id="1615" /> <Component id="1797" /> <Component id="2479" /> <Component id="2593" /> <Component id="2602" /> <Component id="2867" /> <Component id="2872" /> <Component id="2878" /> <Component id="3030" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableCompartment id="3034" reactomeId="70101" position="1312 601" bounds="82 26 2460 1150" textPosition="107 1120" bgColor="250 240 240" lineColor="255 153 102" insets="92 36 2430 1120"> <Properties> <displayName>cytosol</displayName> </Properties> <Components> <Component id="3033" /> </Components> </org.gk.render.RenderableCompartment> </Nodes> <Edges> <org.gk.render.RenderableReaction id="589" reactomeId="9818937" points="459 707, 561 708, 579 685" position="561 708" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="138" points="438 774" /> <Input id="25" points="389 634" /> </Inputs> <Outputs> <Output id="590" /> </Outputs> <Properties> <displayName>MEN1 binds MLL1 complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="721" reactomeId="9818954" points="594 573, 626 566, 669 551" position="626 566" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="590" points="592 643" /> <Input id="722" points="555 570" /> </Inputs> <Outputs> <Output id="723" /> </Outputs> <Properties> <displayName>PSIP1 binds MLL1 and MEN1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="774" reactomeId="9818984" points="815 529, 857 526, 908 528" position="857 526" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1529" points="785 494" /> <Input id="723" points="774 532" /> </Inputs> <Outputs> <Output id="776" /> </Outputs> <Properties> <displayName>The complex of MLL1, MEN1 and PSIP1 binds target gene loci</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="993" reactomeId="9819008" points="399 502, 433 485, 459 486" position="433 485" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="590" points="570 643" /> <Input id="2275" points="371 494" /> </Inputs> <Outputs> <Output id="2369" /> </Outputs> <Properties> <displayName>The complex of MLL1 and MEN1 binds target gene loci</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1172" reactomeId="9819024" points="595 414, 646 399, 689 397" position="646 399" lineWidth="1.0"> <Inputs> <Input id="1177" stoichiometry="6" points="562 392" /> <Input id="2369" points="573 432" /> </Inputs> <Outputs> <Output id="1175" stoichiometry="6" points="681 358" /> <Output id="2436" points="731 386" /> </Outputs> <Catalysts> <Catalyst id="2369" points="598 465, 658 439" /> </Catalysts> <Properties> <displayName>MLL1 complex bound to MEN1 trimethylates nucleosomes at MLL1 target gene loci</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1236" reactomeId="9819040" points="929 412, 904 393, 951 362" position="904 393" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="994" /> </Inputs> <Outputs> <Output id="1237" /> </Outputs> <Activators> <Activator id="2436" points="870 385" /> </Activators> <Properties> <displayName>Expression of MLL1 target genes is positively regulated by MLL1 complex and MEN1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1615" reactomeId="9819144" points="1076 531, 1129 533, 1143 533" position="1129 533" lineWidth="1.0"> <Inputs> <Input id="776" points="1038 531" /> <Input id="1620" stoichiometry="6" points="1066 582" /> </Inputs> <Outputs> <Output id="1616" points="1210 527" /> <Output id="1618" stoichiometry="6" points="1197 582" /> </Outputs> <Catalysts> <Catalyst id="776" points="1038 513, 1080 500" /> </Catalysts> <Properties> <displayName>MLL1 complex bound to MEN1 and PSIP1 trimethylates nucleosomes at target gene promotres</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1797" reactomeId="9819149" points="1222 392, 1266 396, 1309 388" position="1266 396" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="1798" /> </Inputs> <Outputs> <Output id="1800" /> </Outputs> <Activators> <Activator id="1616" points="1285 495" /> </Activators> <Properties> <displayName>Expression of MLL1 target genes is positively regulated by MLL1, MEN1 and PSIP1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2479" reactomeId="9821018" points="918 251, 960 264, 1085 255" position="960 264" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="2480" points="874 251" /> <Input id="2482" points="954 240" /> </Inputs> <Outputs> <Output id="2516" /> </Outputs> <Properties> <displayName>CDX4 binds to HOXA9,HOXA10 gene promoters</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2593" reactomeId="9821070" points="1302 307, 1418 298, 1483 308" position="1418 298" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="2594" /> </Inputs> <Outputs> <Output id="2598" /> </Outputs> <Activators> <Activator id="2516" points="1304 276" /> </Activators> <Properties> <displayName>Expression of HOXA9 gene, (HOXA10 gene) is positively regulated by CDX4</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2602" reactomeId="9821235" points="736 640, 822 688, 901 674" position="822 688" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="2747" points="740 622" /> <Input id="2603" points="715 650" /> </Inputs> <Outputs> <Output id="2786" /> </Outputs> <Properties> <displayName>HCFC1,HCFC2 bind the MLL1:MEN1 complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2867" reactomeId="9821269" points="1214 713, 1243 716, 1286 714" position="1243 716" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="2868" points="1167 716" /> <Input id="2869" points="1170 667" /> </Inputs> <Outputs> <Output id="2870" /> </Outputs> <Properties> <displayName>The complex of HCFC1 and MLL1 is recruited to E2F1 target promoters</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2872" reactomeId="9821277" points="1688 722, 1746 722, 1823 718" position="1746 722" lineWidth="1.0" lineColor="0 0 0"> <Inputs> <Input id="2870" points="1594 717" /> <Input id="2875" stoichiometry="12" points="1669 777" /> </Inputs> <Outputs> <Output id="2873" points="1903 710" /> <Output id="2877" stoichiometry="12" points="1833 762" /> </Outputs> <Catalysts> <Catalyst id="2870" points="1594 689, 1714 672" /> </Catalysts> <Properties> <displayName>MLL1 complex trimethylates nucleosomes at promoters of E2F1 target genes</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2878" reactomeId="9821347" points="1885 572, 1992 593, 2114 560" position="1992 593" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="2879" /> </Inputs> <Outputs> <Output id="2880" /> </Outputs> <Activators> <Activator id="2873" points="1992 660" /> </Activators> <Properties> <displayName>Expression of E2F1 target genes is stimulated by the complex of MLL1 and HCFC1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3030" reactomeId="9821368" points="329 673, 332 693, 334 733" position="332 693" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="25" points="368 634" /> <Input id="3031" points="278 630" /> </Inputs> <Outputs> <Output id="3032" /> </Outputs> <Properties> <displayName>AKAP8L binds MLL1 complex</displayName> </Properties> </org.gk.render.RenderableReaction> </Edges> <Pathways /> </Process> |
| width | 2550 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by Diagram of Epigenetic regulation of gene expression by MLL1 complex (9818679)
