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Details on Person The KMT2A (also known as MLL or MLL1) dimers, produced by th...
| Class:Id | Summation:9818614 |
|---|---|
| _displayName | The KMT2A (also known as MLL or MLL1) dimers, produced by th... |
| _timestamp | 2023-02-10 17:49:19 |
| created | [InstanceEdit:9818613] Orlic-Milacic, Marija, 2022-10-19 |
| literatureReference | [LiteratureReference:9818588] Taspase1: a threonine aspartase required for cleavage of MLL and proper HOX gene expression [LiteratureReference:9818594] Proteolytic cleavage of MLL generates a complex of N- and C-terminal fragments that confers protein stability and subnuclear localization |
| modified | [InstanceEdit:9828082] Orlic-Milacic, Marija, 2023-02-10 [InstanceEdit:9828126] Orlic-Milacic, Marija, 2023-02-10 |
| text | The KMT2A (also known as MLL or MLL1) dimers, produced by the cleavage of KMT2A and subsequent dimerization of two cleaved fragments, translocate to the nucleus. While cleavage and dimerization are not needed for nuclear translocation, they are required for proper subnuclear localization of KMT2A (Hsieh, Ernst et al. 2003; Hsieh, Cheng and Korsmeyer 2003). Hsieh, Ernst et al. 2003, and Hsieh, Cheng and Korsmeyer 2003: Recombinant and endogenous human TASP1 and KMT2A proteins were used, and experiments were performed in human embryonic kidney cell line HEK293. |
| (summation) | [BlackBoxEvent:9818576] Cleaved KMT2A dimers translocate to the nucleus [Homo sapiens] |
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No pathways have been reviewed or authored by The KMT2A (also known as MLL or MLL1) dimers, produced by th... (9818614)
