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Details on Person TASP1 (Threonine aspartase 1), a threonine-type endopeptidas...
| Class:Id | Summation:9818595 |
|---|---|
| _displayName | TASP1 (Threonine aspartase 1), a threonine-type endopeptidas... |
| _timestamp | 2023-02-10 15:26:12 |
| created | [InstanceEdit:9818589] Orlic-Milacic, Marija, 2022-10-19 |
| literatureReference | [LiteratureReference:9818609] Proteolysis of MLL family proteins is essential for taspase1-orchestrated cell cycle progression [LiteratureReference:9818588] Taspase1: a threonine aspartase required for cleavage of MLL and proper HOX gene expression [LiteratureReference:9818594] Proteolytic cleavage of MLL generates a complex of N- and C-terminal fragments that confers protein stability and subnuclear localization [LiteratureReference:9818652] Leukemia proto-oncoprotein MLL is proteolytically processed into 2 fragments with opposite transcriptional properties |
| modified | [InstanceEdit:9818618] Orlic-Milacic, Marija, 2022-10-19 [InstanceEdit:9818655] Orlic-Milacic, Marija, 2022-10-19 [InstanceEdit:9821612] Orlic-Milacic, Marija, 2022-12-09 [InstanceEdit:9823550] Orlic-Milacic, Marija, 2023-01-06 [InstanceEdit:9828081] Orlic-Milacic, Marija, 2023-02-10 |
| text | TASP1 (Threonine aspartase 1), a threonine-type endopeptidase that localizes to the light membrane and cytosolic subcellular fractions, cleaves KMT2A (also known as MLL or MLL1) between an aspartate residue at position 2718 and a glycine residue at position 2719 (Hsieh, Cheng and Korsmeyer 2003; Yokoyama et al. 2002; Hsieh, Ernst et al. 2003). An additional upstream cleavage site exists, but the 2718-2719 cleavage site is preferentially used (Yokoyama et al. 2002; Hsieh, Cheng and Korsmeyer 2003; Hsieh, Ernst et al. 2003). The cleavage produces two fragments commonly known as N320 and C180, which dimerize through their FY-rich N-terminal (FYRN) and FY-rich C-terminal (FYRC) domains, respectively (Yokoyama et al. 2002; Hsieh, Ernst et al. 2003). The cleavage and dimerization are required for KMT2A's proper subnuclear localization and catalytic activity (Hsieh, Ernst et al. 2003; Hsieh, Cheng and Korsmeyer 2003; Takeda et al. 2006). Yokoyama et al. 2002: Recombinant human KMT2A was used. Hsieh, Ernst et al. 2003, and Hsieh, Cheng, and Korsmeyer 2003: Recombinant and endogenous human TASP1 and KMT2A proteins were used, and experiments were performed in human embryonic kidney cell line HEK293. Takeda et al. 2006: endogenous mouse Kmt2a purified from wild type or Tasp1 null mouse embryonic fibroblasts (MEFs) was used in an in vitro methyltransferase assay; H3K4 methylation of Kmt2a-target genes was compared between wild type or Tasp1 null mouse embryonic fibroblasts (MEFs) using chromatin immunoprecipitation (ChIP). |
| (summation) | [Reaction:9818574] TASP1 cleaves KMT2A [Homo sapiens] |
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No pathways have been reviewed or authored by TASP1 (Threonine aspartase 1), a threonine-type endopeptidas... (9818595)
