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Details on Person Diagram of O-linked glycosylation, Defective C1GALT1C1 causes TNPS, Defective GALNT3 causes HFTC, Defective GALNT12 causes CRCS1, Defective B3GALTL causes PpS, Defective LARGE causes MDDGA6 and MDDGB6, Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3, Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1, and Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2
| Class:Id | PathwayDiagram:981850 |
|---|---|
| _displayName | Diagram of O-linked glycosylation, Defective C1GALT1C1 causes TNPS, Defective GALNT3 causes HFTC, Defective GALNT12 causes CRCS1, Defective B3GALTL causes PpS, Defective LARGE causes MDDGA6 and MDDGB6, Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3, Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1, and Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 |
| _timestamp | 2025-10-30 22:10:58 |
| created | [InstanceEdit:981849] Jassal, B, 2010-10-28 |
| height | 1466 |
| modified | [InstanceEdit:1679954] Wu, G, 2011-10-20 [InstanceEdit:1964511] Jassal, B, 2011-11-04 [InstanceEdit:1965758] Jassal, B, 2011-11-04 [InstanceEdit:1965759] Jassal, B, 2011-11-04 [InstanceEdit:1967038] Jassal, B, 2011-11-04 [InstanceEdit:1968258] Jassal, B, 2011-11-04 [InstanceEdit:3008837] Gillespie, ME, 2013-02-01 [InstanceEdit:4551779] Jassal, B, 2013-09-16 [InstanceEdit:5187643] Jassal, B, 2013-12-02 [InstanceEdit:5191520] Jassal, B, 2013-12-02 [InstanceEdit:5195406] Jassal, B, 2013-12-02 [InstanceEdit:5199275] Jassal, B, 2013-12-03 [InstanceEdit:5617054] Jassal, Bijay, 2014-07-30 [InstanceEdit:5674048] Wu, G, 2015-02-10 [InstanceEdit:5674149] Jassal, Bijay, 2015-02-11 [InstanceEdit:5674150] Jassal, Bijay, 2015-02-11 [InstanceEdit:6784245] Jassal, Bijay, 2015-06-19 [InstanceEdit:6784301] Jassal, Bijay, 2015-06-19 [InstanceEdit:6785501] Jassal, Bijay, 2015-06-29 [InstanceEdit:6785539] Jassal, Bijay, 2015-06-29 [InstanceEdit:6785549] Jassal, Bijay, 2015-06-29 [InstanceEdit:6785558] Jassal, Bijay, 2015-06-29 [InstanceEdit:6785574] Jassal, Bijay, 2015-06-29 [InstanceEdit:6785673] Jassal, Bijay, 2015-06-30 [InstanceEdit:6793925] Jassal, Bijay, 2015-09-04 [InstanceEdit:8851015] Jassal, Bijay, 2016-01-05 [InstanceEdit:8855180] Wu, G, 2016-02-02 [InstanceEdit:8931842] Jassal, Bijay, 2016-07-19 [InstanceEdit:8931883] Jassal, Bijay, 2016-07-19 [InstanceEdit:8932261] Jassal, Bijay, 2016-07-22 [InstanceEdit:8932269] Jassal, Bijay, 2016-07-22 [InstanceEdit:8932434] Jassal, Bijay, 2016-07-25 [InstanceEdit:8932521] Jassal, Bijay, 2016-07-26 [InstanceEdit:8932528] Jassal, Bijay, 2016-07-26 [InstanceEdit:8932529] Jassal, Bijay, 2016-07-26 [InstanceEdit:8932530] Jassal, Bijay, 2016-07-26 [InstanceEdit:8932531] Jassal, Bijay, 2016-07-26 [InstanceEdit:8936255] Jassal, Bijay, 2016-08-17 [InstanceEdit:9638095] Jassal, Bijay, 2019-02-25 [InstanceEdit:9645116] Wu, G, 2019-05-03 [InstanceEdit:9689742] Jassal, Bijay, 2020-05-21 [InstanceEdit:9697717] Jassal, Bijay, 2020-08-20 [InstanceEdit:9697722] Jassal, Bijay, 2020-08-20 [InstanceEdit:9737553] Jassal, Bijay, 2021-07-20 [InstanceEdit:9756045] Jassal, Bijay, 2021-10-12 [InstanceEdit:9756078] Jassal, Bijay, 2021-10-12 [InstanceEdit:9935481] D'Eustachio, Peter, 2025-01-14 [InstanceEdit:9936123] D'Eustachio, Peter, 2025-01-20 [InstanceEdit:9940909] Stephan, Ralf, 2025-03-06 [InstanceEdit:9940987] Stephan, Ralf, 2025-03-07 [InstanceEdit:9940988] Stephan, Ralf, 2025-03-07 [InstanceEdit:9941578] Stephan, Ralf, 2025-03-09 [InstanceEdit:9941601] Stephan, Ralf, 2025-03-10 [InstanceEdit:9942326] Stephan, Ralf, 2025-03-14 [InstanceEdit:9942382] Stephan, Ralf, 2025-03-15 [InstanceEdit:9942394] Stephan, Ralf, 2025-03-16 [InstanceEdit:9942598] Stephan, Ralf, 2025-03-18 [InstanceEdit:9942599] Stephan, Ralf, 2025-03-18 [InstanceEdit:9944932] Stephan, Ralf, 2025-04-08 [InstanceEdit:9948073] Stephan, Ralf, 2025-05-15 [InstanceEdit:9948473] Stephan, Ralf, 2025-05-21 [InstanceEdit:9953215] Stephan, Ralf, 2025-05-29 [InstanceEdit:9970573] D'Eustachio, Peter, 2025-10-30 |
| representedPathway | [Pathway:5173105] O-linked glycosylation [Homo sapiens] [Pathway:5083632] Defective C1GALT1C1 causes TNPS [Homo sapiens] [Pathway:5083625] Defective GALNT3 causes HFTC [Homo sapiens] [Pathway:5083636] Defective GALNT12 causes CRCS1 [Homo sapiens] [Pathway:5083635] Defective B3GALTL causes PpS [Homo sapiens] [Pathway:5083627] Defective LARGE causes MDDGA6 and MDDGB6 [Homo sapiens] [Pathway:5083628] Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 [Homo sapiens] [Pathway:5083633] Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 [Homo sapiens] [Pathway:5083629] Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 [Homo sapiens] |
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reactomeId="425969" position="221 516" bounds="208 503 26 26" textPosition="212 498" /> <org.gk.render.RenderableChemical id="3629" reactomeId="425969" position="805 408" bounds="792 395 26 26" textPosition="796 390" /> <org.gk.render.RenderableChemical id="3631" reactomeId="425969" position="1576 370" bounds="1563 357 26 26" textPosition="1567 352" /> <org.gk.render.RenderableChemical id="3636" reactomeId="425969" position="1631 623" bounds="1618 610 26 26" textPosition="1622 605"> <Properties> <displayName>H+</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="3644" reactomeId="425969" position="217 695" bounds="204 682 26 26" textPosition="208 677" /> <org.gk.render.RenderableChemical id="3649" reactomeId="425969" position="344 911" bounds="331 898 26 26" textPosition="335 893" /> <org.gk.render.RenderableChemical id="3660" reactomeId="425969" position="389 276" bounds="376 263 26 26" textPosition="380 258" /> <org.gk.render.RenderableChemical id="3665" reactomeId="425969" position="1068 444" bounds="1055 431 26 26" textPosition="1059 426" /> <org.gk.render.RenderableChemical id="3667" reactomeId="425969" position="1185 436" bounds="1172 423 26 26" textPosition="1176 418" /> <org.gk.render.ProcessNode id="3668" reactomeId="174362" position="1258 960" bounds="1189 936 138 49" textPosition="1193 938"> <Properties> <displayName>Transport and metabolism of PAPS</displayName> </Properties> </org.gk.render.ProcessNode> <org.gk.render.ProcessNode id="3675" reactomeId="446203" position="2125 678" bounds="2057 652 136 53" textPosition="2055 656"> <Properties> <displayName>Asparagine N-linked glycosylation</displayName> </Properties> </org.gk.render.ProcessNode> <org.gk.render.RenderableProtein id="3690" reactomeId="9940790" position="785 1310" bounds="754 1299 62 23" textPosition="758 1299"> <Properties> <displayName>RXYLT1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="3691" reactomeId="6785687" position="859 1310" bounds="836 1293 46 35" textPosition="838 1292" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>FKRP dimer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="3692" reactomeId="6785689" position="708 1312" bounds="685 1301 47 23" textPosition="689 1301"> <Properties> <displayName>FKTN</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="3694" reactomeId="9942327" position="954 1319" bounds="916 1302 76 35" textPosition="918 1301" bgColor="204 255 255" hideComponents="true" /> <org.gk.render.RenderableChemical id="3695" reactomeId="1463452" position="2354 414" bounds="2320 399 68 31" textPosition="2324 403" /> <org.gk.render.RenderableChemical id="3699" reactomeId="1463452" position="1869 501" bounds="1835 486 68 31" textPosition="1839 490"> <Properties> <displayName>GDP-Fuc</displayName> </Properties> </org.gk.render.RenderableChemical> </Nodes> <Edges> <org.gk.render.RenderableReaction id="2" reactomeId="913675" points="260 434, 261 457, 261 494" position="261 457" lineWidth="1.0"> <Inputs> <Input id="3" points="310 420" /> <Input id="3619" points="259 403" /> </Inputs> <Outputs> <Output id="5" points="492 494" /> <Output id="6" points="261 532" /> <Output id="3624" points="237 508" /> </Outputs> <Catalysts> <Catalyst id="1900" points="218 457" /> </Catalysts> <Properties> <displayName>GALNTs transfer GalNAc to Mucins to form Tn antigens</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="13" reactomeId="914012" points="1630 306, 1670 306, 1667 335" position="1670 306" lineWidth="1.0"> <Inputs> <Input id="146" points="866 329, 935 197, 1569 197" /> <Input id="130" points="1602 306" /> </Inputs> <Outputs> <Output id="198" points="1592 407" /> <Output id="17" points="1675 365" /> <Output id="3631" points="1592 365" /> </Outputs> <Catalysts> <Catalyst id="15" points="1670 257" /> </Catalysts> <Properties> <displayName>GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="23" reactomeId="914010" points="320 602, 274 626, 274 675" position="274 626" lineWidth="1.0"> <Inputs> <Input id="5" points="513 512" /> <Input id="24" points="455 614" /> </Inputs> <Outputs> <Output id="217" points="327 684" /> <Output id="3644" points="233 690" /> <Output id="28" points="274 724" /> </Outputs> <Catalysts> <Catalyst id="26" points="207 624" /> </Catalysts> <Properties> <displayName>B3GNT6 transfers GlcNAc to Tn antigen</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="30" reactomeId="914018" points="365 796, 365 826, 366 851" position="365 826" lineWidth="1.0"> <Inputs> <Input id="24" points="472 638" /> <Input id="217" points="365 718" /> </Inputs> <Outputs> <Output id="270" points="414 864" /> <Output id="3649" points="348 895" /> <Output id="34" points="323 873" /> </Outputs> <Catalysts> <Catalyst id="32" points="200 826" /> </Catalysts> <Properties> <displayName>GCNT3 transfers GlcNAc to Core 3 mucin</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="38" reactomeId="914005" points="747 642, 790 642, 857 642" position="790 642" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="5" points="551 512" /> <Input id="24" points="515 619" /> </Inputs> <Outputs> <Output id="293" points="914 625" /> <Output id="44" points="936 714" /> </Outputs> <Properties> <displayName>Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="41" reactomeId="914008" points="713 668, 793 668, 854 668" position="793 668" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="5" points="547 512" /> <Input id="24" points="515 623" /> </Inputs> <Outputs> <Output id="299" points="944 668" /> <Output id="44" points="929 718" /> </Outputs> <Properties> <displayName>Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="75" reactomeId="914017" points="626 732, 686 732, 780 732" position="686 732" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="5" points="540 512" /> <Input id="78" points="546 756" /> </Inputs> <Outputs> <Output id="308" points="928 778" /> <Output id="44" points="929 732" /> </Outputs> <Properties> <displayName>Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="80" reactomeId="914006" points="628 782, 664 782, 767 782" position="664 782" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="5" points="539 512" /> <Input id="82" points="575 828" /> </Inputs> <Outputs> <Output id="315" points="927 828" /> <Output id="44" points="929 737" /> </Outputs> <Properties> <displayName>Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="88" reactomeId="977071" points="536 343, 536 298, 495 297" position="536 298" lineWidth="1.0"> <Inputs> <Input id="5" points="536 478" /> <Input id="89" points="499 373" /> </Inputs> <Outputs> <Output id="90" points="469 280" /> <Output id="316" points="457 313" /> <Output id="3660" points="405 278" /> </Outputs> <Catalysts> <Catalyst id="92" points="536 254" /> </Catalysts> <Properties> <displayName>ST6GAL1 transfers sialic acid to Tn antigens to form sTn antigens</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="106" reactomeId="981814" points="956 314, 1031 314, 1064 380" position="1031 314" lineWidth="1.0"> <Inputs> <Input id="146" points="893 329" /> <Input id="194" points="956 293" /> </Inputs> <Outputs> <Output id="489" points="976 459" /> <Output id="3665" points="1067 428" /> <Output id="113" points="1105 446" /> </Outputs> <Catalysts> <Catalyst id="107" points="1031 255" /> </Catalysts> <Properties> <displayName>ST6GALNAC2 transfers sialic acid to Core 1 mucins</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="115" reactomeId="981497" points="1104 346, 1154 346, 1140 396" position="1154 346" lineWidth="1.0"> <Inputs> <Input id="146" points="913 346" /> <Input id="111" points="1095 317" /> </Inputs> <Outputs> <Output id="541" points="1267 363" /> <Output id="3667" points="1169 424" /> <Output id="113" points="1120 446" /> </Outputs> <Catalysts> <Catalyst id="117" points="1153 260" /> </Catalysts> <Properties> <displayName>ST3GAL1-4 transfers sialic acid to the T antigen at the alpha 3 position</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="122" reactomeId="981809" points="1397 344, 1438 344, 1454 374" position="1438 344" lineWidth="1.0"> <Inputs> <Input id="541" points="1374 344" /> <Input id="126" points="1364 313" /> </Inputs> <Outputs> <Output id="585" points="1440 439" /> <Output id="3631" points="1560 370" /> <Output id="128" points="1479 397" /> </Outputs> <Catalysts> <Catalyst id="124" points="1438 260" /> </Catalysts> <Properties> <displayName>ST6GALNAC3/4 transfers sialic acid to the sialyl T antigen to form the disialyl T antigen</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="586" points="166 813, 121 703, 121 175, 1670 175, 1670 223" position="121 175" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="32" /> </Inputs> <Outputs> <Output id="15" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableReaction id="587" reactomeId="1964505" points="679 346, 711 346, 739 346" position="711 346" lineWidth="1.0"> <Inputs> <Input id="5" points="546 478" /> <Input id="10" points="627 291" /> </Inputs> <Outputs> <Output id="146" points="809 346" /> <Output id="3629" points="789 395" /> <Output id="19" points="765 323" /> </Outputs> <Catalysts> <Catalyst id="588" points="711 264" /> </Catalysts> <Properties> <displayName>C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="674" reactomeId="1964501" points="1099 669, 1099 698, 1099 721" position="1099 698" lineWidth="1.0"> <Inputs> <Input id="299" points="1048 669" /> <Input id="678" points="1120 653" /> </Inputs> <Outputs> <Output id="754" points="1099 773" /> <Output id="44" points="976 730" /> </Outputs> <Catalysts> <Catalyst id="755" points="1140 697" /> </Catalysts> <Properties> <displayName>Addition of galactose to Core 6 glycoprotein</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="757" reactomeId="5173192" points="1908 437, 1924 435, 1945 435" position="1924 435" lineWidth="1.0"> <Inputs> <Input id="758" points="1886 435" /> <Input id="3699" points="1878 483" /> </Inputs> <Outputs> <Output id="3608" points="1954 485" /> <Output id="759" points="1966 435" /> <Output id="3610" points="1991 489" /> </Outputs> <Catalysts> <Catalyst id="760" points="1923 369" /> </Catalysts> <Properties> <displayName>POFUT2 transfers fucose to TSR domain-containing proteins</displayName> <isChanged>true</isChanged> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="761" reactomeId="5173005" points="2090 435, 2110 435, 2125 435" position="2110 435" lineWidth="1.0"> <Inputs> <Input id="1303" points="2057 405" /> <Input id="759" points="2052 435" /> </Inputs> <Outputs> <Output id="1305" points="2166 462" /> <Output id="762" points="2195 435" /> </Outputs> <Catalysts> <Catalyst id="763" points="2110 368" /> </Catalysts> <Properties> <displayName>B3GALTL transfers glucose to O-fucosyl-proteins</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="796" reactomeId="5694487" points="1637 468, 1669 485, 1669 508" position="1669 485" lineWidth="1.0"> <Inputs> <Input id="198" points="1595 441" /> <Input id="799" points="1656 459" /> </Inputs> <Outputs> <Output id="802" points="1669 549" /> <Output id="801" points="1637 523" /> </Outputs> <Catalysts> <Catalyst id="797" points="1702 484" /> </Catalysts> <Properties> <displayName>A4GNT transfers GlcNAc to core 2 mucins</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1060" reactomeId="5617143" points="846 1248, 821 1247, 791 1247" position="821 1247" lineWidth="1.0"> <Inputs> <Input id="2707" points="870 1196" /> <Input id="3454" points="872 1248" /> </Inputs> <Outputs> <Output id="3456" points="737 1247" /> <Output id="3533" points="749 1195" /> <Output id="3537" points="769 1167" /> </Outputs> <Catalysts> <Catalyst id="3364" points="603 1297, 778 1278" /> </Catalysts> <Properties> <displayName>B4GAT1:LARGE transfers initial GlcA to matriglycan chain</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1895" reactomeId="6786012" points="1543 484, 1593 585, 1593 611" position="1593 585" lineWidth="1.0"> <Inputs> <Input id="1896" points="1452 494" /> <Input id="198" points="1574 441" /> </Inputs> <Outputs> <Output id="1897" points="1560 614" /> <Output id="1898" points="1593 638" /> <Output id="3636" points="1615 618" /> </Outputs> <Catalysts> <Catalyst id="1899" points="1711 613" /> </Catalysts> <Properties> <displayName>CHST4 transfers SO4(2-) from PAPS to Core 2 mucins</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2292" reactomeId="5617037" points="1658 787, 1659 810, 1658 836" position="1659 810" lineWidth="1.0"> <Inputs> <Input id="3484" points="1658 732" /> <Input id="3579" stoichiometry="2" points="1602 766" /> </Inputs> <Outputs> <Output id="1050" points="1659 892" /> <Output id="2268" stoichiometry="2" points="1679 851" /> <Output id="3594" stoichiometry="2" points="1578 862" /> </Outputs> <Catalysts> <Catalyst id="3595" points="1689 810" /> </Catalysts> <Properties> <displayName>POMGNT1 transfers GlcNAc from UDP-GlcNAc to Man-O-Ser-DAG1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3363" reactomeId="9638097" points="326 1244, 302 1245, 265 1245" position="302 1245" lineWidth="1.0"> <Inputs> <Input id="3458" points="358 1244" /> <Input id="3528" points="356 1195" /> </Inputs> <Outputs> <Output id="3459" points="248 1213" /> <Output id="3268" points="235 1244" /> <Output id="3535" points="241 1269" /> </Outputs> <Catalysts> <Catalyst id="3364" points="498 1301, 311 1294" /> </Catalysts> <Properties> <displayName>LARGE1,2 elongates matriglycan chain with GlcA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3411" reactomeId="9638090" points="573 1246, 549 1246, 524 1246" position="549 1246" lineWidth="1.0"> <Inputs> <Input id="3456" points="610 1246" /> <Input id="3526" points="607 1193" /> </Inputs> <Outputs> <Output id="3455" points="436 1157" /> <Output id="3458" points="491 1246" /> <Output id="3266" points="499 1178" /> </Outputs> <Catalysts> <Catalyst id="3364" points="549 1289" /> </Catalysts> <Properties> <displayName>LARGE1,2 elongates matriglycan chain with Xyl</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3415" reactomeId="9935449" points="2419 430, 2452 428, 2491 427" position="2452 428" lineWidth="1.0"> <Inputs> <Input id="3451" points="2357 464" /> <Input id="3695" points="2391 422" /> </Inputs> <Outputs> <Output id="3418" points="2522 404" /> <Output id="3453" points="2570 445" /> <Output id="3558" points="2515 510" /> </Outputs> <Catalysts> <Catalyst id="3421" points="2418 364" /> </Catalysts> <Properties> <displayName>FUT10 O-fucosylates EMI domain-containing proteins</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3428" reactomeId="9935469" points="2418 476, 2459 476, 2488 475" position="2459 476" lineWidth="1.0"> <Inputs> <Input id="3451" points="2385 478" /> <Input id="3695" points="2370 433" /> </Inputs> <Outputs> <Output id="3418" points="2535 410" /> <Output id="3453" points="2550 467" /> <Output id="3558" points="2510 510" /> </Outputs> <Catalysts> <Catalyst id="3429" points="2498 365" /> </Catalysts> <Properties> <displayName>FUT11 O-fucosylates EMI domain-containing proteins</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3460" reactomeId="5615637" points="2603 617, 2603 641, 2603 667" position="2603 641" lineWidth="1.0"> <Inputs> <Input id="2335" stoichiometry="3" points="2518 587" /> <Input id="2179" points="2602 582" /> </Inputs> <Outputs> <Output id="775" points="2603 694" /> <Output id="2336" stoichiometry="3" points="2521 681" /> <Output id="3462" stoichiometry="3" points="2633 675" /> </Outputs> <Catalysts> <Catalyst id="776" points="2658 641" /> </Catalysts> <Properties> <displayName>POMT1:POMT2 transfers Man from Dol-P-Man to DAG1(30-653)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3463" reactomeId="8879117" points="2603 803, 2603 825, 2604 849" position="2603 825" lineWidth="1.0"> <Inputs> <Input id="775" points="2603 722" /> <Input id="2196" points="2536 794" /> </Inputs> <Outputs> <Output id="2071" points="2506 947" /> <Output id="3465" points="2635 860" /> <Output id="3560" points="2563 861" /> </Outputs> <Catalysts> <Catalyst id="2072" points="2636 823" /> </Catalysts> <Properties> <displayName>POMGNT2 transfers GlcNAc to Man-DAG1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3469" reactomeId="8931648" points="2332 1001, 2304 1001, 2279 1000" position="2304 1001" lineWidth="1.0"> <Inputs> <Input id="2071" points="2451 976" /> <Input id="2227" points="2355 959" /> </Inputs> <Outputs> <Output id="2079" points="2211 1000" /> <Output id="3419" points="2268 1036" /> <Output id="3571" points="2241 925" /> </Outputs> <Catalysts> <Catalyst id="2080" points="2324 1064" /> </Catalysts> <Properties> <displayName>B3GALNT2 transfers GalNAc to GlcNAc-Man-DAG1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3470" reactomeId="8931653" points="2049 1000, 2023 1000, 2000 1000" position="2023 1000" lineWidth="1.0"> <Inputs> <Input id="2079" points="2099 1000" /> <Input id="2238" points="2050 960" /> </Inputs> <Outputs> <Output id="2088" points="1954 1000" /> <Output id="2239" points="1962 944" /> <Output id="3474" points="1982 1023" /> </Outputs> <Catalysts> <Catalyst id="2090" points="2024 1056" /> </Catalysts> <Properties> <displayName>POMK 6-phosphorylates mannose in GalNAc-GlcNAc-Man-DAG1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3483" reactomeId="9940714" points="1892 980, 1802 708, 1709 708" position="1802 708" lineWidth="1.0" reactionType="Uncertain Process"> <Inputs> <Input id="2088" /> </Inputs> <Outputs> <Output id="3484" /> </Outputs> <Properties> <displayName>Glycosylated alpha-DAG1 localizes to Golgi</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3485" reactomeId="9940844" points="1874 1375, 1842 1376, 1808 1376" position="1842 1376" lineWidth="1.0"> <Inputs> <Input id="3486" points="1941 1375" /> <Input id="3487" points="1948 1346" /> <Input id="3488" points="1955 1405" /> </Inputs> <Outputs> <Output id="3489" points="1751 1375" /> <Output id="3490" points="1786 1404" /> </Outputs> <Catalysts> <Catalyst id="3491" points="1841 1329" /> </Catalysts> <Properties> <displayName>CRPPA dimer transfers cytidylyl to Rbt5P</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3495" reactomeId="9940804" points="1632 1312, 1632 1310, 1632 1311" position="1632 1310" lineWidth="1.0"> <Inputs> <Input id="3489" points="1688 1356" /> <Input id="3496" points="1613 1300" /> </Inputs> <Outputs> <Output id="3497" points="1606 1338" /> <Output id="3498" points="1641 1265" /> </Outputs> <Catalysts> <Catalyst id="3499" points="1666 1311" /> </Catalysts> <Properties> <displayName>SLC35A1,4 import CDP-ribitol</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3500" reactomeId="9940735" points="1562 1221, 1524 1221, 1488 1225" position="1524 1221" lineWidth="1.0"> <Inputs> <Input id="3565" points="1645 1140" /> <Input id="3498" points="1601 1233" /> </Inputs> <Outputs> <Output id="3501" points="1445 1233" /> <Output id="3505" points="1470 1147" /> <Output id="3514" points="1432 1170" /> </Outputs> <Catalysts> <Catalyst id="3502" points="1316 1306, 1509 1267" /> </Catalysts> <Properties> <displayName>FKTN transfers RboP to GalNAc-GlcNAc-ManP-DAG1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3515" reactomeId="9940756" points="1311 1245, 1284 1245, 1256 1245" position="1284 1245" lineWidth="1.0"> <Inputs> <Input id="3498" points="1601 1254, 1393 1302" /> <Input id="3501" points="1343 1244" /> </Inputs> <Outputs> <Output id="3516" points="1220 1246" /> <Output id="3518" points="1238 1204" /> <Output id="3510" points="1243 1264" /> </Outputs> <Catalysts> <Catalyst id="3502" points="1283 1285" /> </Catalysts> <Properties> <displayName>FKRP dimer transfers RboP to matriglycan chain</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3519" reactomeId="9940805" points="1082 1246, 1054 1247, 1021 1247" position="1054 1247" lineWidth="1.0"> <Inputs> <Input id="3516" points="1119 1246" /> <Input id="2701" points="1102 1200" /> </Inputs> <Outputs> <Output id="3454" points="974 1248" /> <Output id="3521" points="996 1202" /> <Output id="3512" points="1011 1272" /> </Outputs> <Catalysts> <Catalyst id="3502" points="1250 1309, 1090 1289" /> </Catalysts> <Properties> <displayName>RXYLT1 transfers initial Xyl to matriglycan chain</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3538" reactomeId="9940718" points="249 1153, 249 1125, 249 1098" position="249 1125" lineWidth="1.0"> <Inputs> <Input id="3459" points="244 1180" /> <Input id="3553" points="286 1164" /> </Inputs> <Outputs> <Output id="3455" points="408 1137" /> <Output id="3539" points="249 1044" /> <Output id="3542" points="291 1081" /> </Outputs> <Catalysts> <Catalyst id="3540" points="207 1124" /> </Catalysts> <Properties> <displayName>CHST10 sulfates matriglycan chain</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3564" reactomeId="8932427" points="1659 981, 1660 1014, 1660 1036" position="1660 1014" lineWidth="1.0"> <Inputs> <Input id="1050" points="1659 934" /> <Input id="2270" points="1613 976" /> </Inputs> <Outputs> <Output id="3565" points="1661 1101" /> <Output id="3587" points="1617 1058" /> <Output id="3604" points="1683 1054" /> </Outputs> <Catalysts> <Catalyst id="3599" points="1698 1014" /> </Catalysts> <Properties> <displayName>MGAT5B transfers GlcNAc from UDP-GlcNAc to GlcNAc-Man-DAG1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="3669" interactionType="Activate" points="1266 933, 1420 515" position="1343 724" lineWidth="2.0"> <Inputs> <Input id="3668" /> </Inputs> <Outputs> <Output id="1896" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="3674" interactionType="Activate" points="1186 965, 504 1022, 330 1153" position="504 1022" lineWidth="2.0"> <Inputs> <Input id="3668" /> </Inputs> <Outputs> <Output id="3553" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="3676" interactionType="Activate" points="2196 657, 2433 586" position="2314 621" lineWidth="2.0"> <Inputs> <Input id="3675" /> </Inputs> <Outputs> <Output id="2335" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="3689" reactomeId="9948070" points="934 1380, 936 1379, 1250 1318" position="936 1379" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="3690" points="809 1325" /> <Input id="3691" points="877 1331" /> <Input id="3692" points="735 1319" /> </Inputs> <Outputs> <Output id="3502" /> </Outputs> <Catalysts> <Catalyst id="3694" points="948 1340" /> </Catalysts> <Properties> <displayName>POMGNT1 catalyzes FKRP:FKTN:RXYLT1 formation</displayName> </Properties> </org.gk.render.RenderableReaction> </Edges> <Pathways /> </Process> |
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No pathways have been reviewed or authored by Diagram of O-linked glycosylation, Defective C1GALT1C1 causes TNPS, Defective GALNT3 causes HFTC, Defective GALNT12 causes CRCS1, Defective B3GALTL causes PpS, Defective LARGE causes MDDGA6 and MDDGB6, Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3, Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1, and Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 (981850)
