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Details on Person MLL3 monomethylates nucleosomes at target gene loci

Class:Id	Reaction:9818167
_displayName	MLL3 monomethylates nucleosomes at target gene loci
_doRelease	FALSE
_timestamp	2022-10-19 13:38:53
catalystActivity	[CatalystActivity:9818171] histone H3K4 methyltransferase activity of MLL3 complex:MLL3 target genes:Nucleosomes [nucleoplasm]
created	[InstanceEdit:9818163] Orlic-Milacic, Marija, 2022-10-12
input	[Complex:9818172] MLL3 complex:MLL3 target genes:Nucleosomes [nucleoplasm] [Homo sapiens] [SimpleEntity:77087] AdoMet [nucleoplasm]
isChimeric	FALSE
literatureReference	[LiteratureReference:9818191] The MLL3/MLL4 branches of the COMPASS family function as major histone H3K4 monomethylases at enhancers [LiteratureReference:9818192] The MLL3/4 H3K4 methyltransferase complex in establishing an active enhancer landscape
modified	[InstanceEdit:9818215] Orlic-Milacic, Marija, 2022-10-12 [InstanceEdit:9818583] Orlic-Milacic, Marija, 2022-10-19
name	MLL3 monomethylates nucleosomes at target gene loci
output	[Complex:9818165] MLL3 complex:MLL3 target genes with H3K4 monomethylated nucleosomes [nucleoplasm] [Homo sapiens] [SimpleEntity:77502] AdoHcy [nucleoplasm]
precedingEvent	[Reaction:9818164] MLL3 binds target gene loci [Homo sapiens] [Reaction:9676254] Formation of the MLL3 complex [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9818180] R-HSA-9818167.1
summation	[Summation:9818166] MLL3/MLL4 are paralogous histone modifiers and are responsib...
(hasEvent)	[Pathway:9818563] Epigenetic regulation of gene expression by MLL3 complex [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9818168] MLL3 positively regulates transcription of target genes [Homo sapiens]
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No pathways have been reviewed or authored by MLL3 monomethylates nucleosomes at target gene loci (9818167)