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Details on Person MLL2 trimethylates nucleosomes at target gene loci

Class:Id	Reaction:9818134
_displayName	MLL2 trimethylates nucleosomes at target gene loci
_doRelease	FALSE
_timestamp	2022-10-19 13:38:49
catalystActivity	[CatalystActivity:9818140] histone H3K4 methyltransferase activity of MLL2 complex:MLL2 target genes:Nucleosomes [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9818142] Orlic-Milacic, Marija, 2022-10-12
input	[Complex:9818147] MLL2 complex:MLL2 target genes:Nucleosomes [nucleoplasm] [Homo sapiens] [SimpleEntity:77087] AdoMet [nucleoplasm]
isChimeric	FALSE
literatureReference	[LiteratureReference:9818145] Not All H3K4 Methylations Are Created Equal: Mll2/COMPASS Dependency in Primordial Germ Cell Specification [LiteratureReference:9771324] Structure, Activity and Function of the MLL2 (KMT2B) Protein Lysine Methyltransferase
modified	[InstanceEdit:9818583] Orlic-Milacic, Marija, 2022-10-19
name	MLL2 trimethylates nucleosomes at target gene loci
output	[Complex:9818138] MLL2 complex:MLL2 target genes with H3K4Me3 nucleosomes [nucleoplasm] [Homo sapiens] [SimpleEntity:77502] AdoHcy [nucleoplasm]
precedingEvent	[Reaction:9818148] MLL2 binds target gene loci [Homo sapiens] [Reaction:9676255] Formation of the MLL2 complex [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9818158] R-HSA-9818134.1
summation	[Summation:9818133] MLL2 complex is responsible for H3K4 trimethylation (H3K4me3...
(precedingEvent)	[BlackBoxEvent:9818135] MLL2 positively regulates transcription of target genes [Homo sapiens]
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