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Details on Person MLL1 facilitates mono, di, and tri methylation of H3K4 (H3K4...

Class:IdSummation:9818065
_displayNameMLL1 facilitates mono, di, and tri methylation of H3K4 (H3K4...
_timestamp2022-12-05 18:56:50
created[InstanceEdit:9818062] Orlic-Milacic, Marija, 2022-10-12
modified[InstanceEdit:9820447] Orlic-Milacic, Marija, 2022-11-07
[InstanceEdit:9821509] Orlic-Milacic, Marija, 2022-12-05
textMLL1 facilitates mono, di, and tri methylation of H3K4 (H3K4me1, H3K4me2, and H3K4me3). H3K4 methylation mediated by MLL1 is found at gene promoters, transcription start sites, and 5’ transcribed regions of target genes.

Global analysis of histone H3K4 methylation and gene expression in the presence or absence of MLL histone methyltransferase family members in mouse embryonic fibroblasts (MEFs) implies that menin-containing Mll1/Mll2 complexes in mediating the majority of H3K4 trimethylation at Hox loci and serving as key regulators of Hox transcription menin-containing Mll1/Mll2 complexes are involved in mediating the majority of H3K4 trimethylation at Hox loci and serving as key regulators of Hox transcription, while the Set1A/Set1B and Mll3/Mll4 complexes have relatively minor roles in controlling Hox expression in MEFs (Wang et al. 2009).

SET1A and SET1B complexes show higher level of histone methyltransferase activity than MLL1-4 complexes and appear to be responsible for global H3K4 trimethylation, while the role of MLL1-4 is restricted to much smaller number of gene loci (Wu et al. 2008).
(summation)[Pathway:9677047] Epigenetic regulation of gene expression by MLL complexes [Homo sapiens]
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