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Details on Person MLL1 methylates nucleosomes at target gene loci

Class:Id	Reaction:9818057
_displayName	MLL1 methylates nucleosomes at target gene loci
_doRelease	FALSE
_timestamp	2022-10-19 13:38:43
catalystActivity	[CatalystActivity:9818069] histone H3K4 methyltransferase activity of MLL1 complex:MLL1 target genes:Nucleosomes [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9818062] Orlic-Milacic, Marija, 2022-10-12
input	[Complex:9818060] MLL1 complex:MLL1 target genes:Nucleosomes [nucleoplasm] [Homo sapiens] [SimpleEntity:77087] AdoMet [nucleoplasm]
isChimeric	FALSE
literatureReference	[LiteratureReference:9772522] Targeting MLL1 H3K4 methyltransferase activity in mixed-lineage leukemia [LiteratureReference:9818089] Global and Hox-specific roles for the MLL1 methyltransferase
modified	[InstanceEdit:9818093] Orlic-Milacic, Marija, 2022-10-12 [InstanceEdit:9818159] Orlic-Milacic, Marija, 2022-10-12 [InstanceEdit:9818583] Orlic-Milacic, Marija, 2022-10-19
name	MLL1 methylates nucleosomes at target gene loci
output	[Complex:9818066] MLL1 complex:MLL1 target genes with H3K4 methylated nucleosomes [nucleoplasm] [Homo sapiens] [SimpleEntity:77502] AdoHcy [nucleoplasm]
precedingEvent	[Reaction:9818058] MLL1 binds target gene loci [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9818072] R-HSA-9818057.1
summation	[Summation:9818070] MLL1 facilitates mono, di, and tri methylation of H3K4 (H3K4...
(hasEvent)	[Pathway:9818561] Epigenetic regulation of gene expression by MLL1 complex [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9818090] MLL1 positively regulates transcription of target genes [Homo sapiens]
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No pathways have been reviewed or authored by MLL1 methylates nucleosomes at target gene loci (9818057)