Reactome: A Curated Pathway Database
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Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

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Details on Person Subpathway representing cytoprotective genes regulated by NF...

Class:IdSummation:9818024
_displayNameSubpathway representing cytoprotective genes regulated by NF...
_timestamp2022-10-20 22:23:36
created[InstanceEdit:9818037] Tiwari, Krishna, 2022-10-10
literatureReference[LiteratureReference:9818754] Transcriptional Regulation by Nrf2
[LiteratureReference:9818725] Nrf2-ARE signaling in cellular protection: Mechanism of action and the regulatory mechanisms
modified[InstanceEdit:9818047] Tiwari, Krishna, 2022-10-10
[InstanceEdit:9818736] Tiwari, Krishna, 2022-10-20
textSubpathway representing cytoprotective genes regulated by NFE2L2 (NRF2). NFE2L2 is well-studied for its role in oxidative stress where it gets activated by ROS and then induces a plethora of gene expression regulation the oxidative damage. It induces genes/enzymes that regulate the phase 2 detoxification system (eg. GSTs and Glutathione system), ROS scavenging (SODs,PRDX1 ) and cytoprotection (HO1) by regulating inflammation and tissue damage (Tonelli et al, 2018; Shaw et al, 2020)
(summation)[Pathway:9818027] NFE2L2 regulating anti-oxidant/detoxification enzymes [Homo sapiens]
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