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Details on Person Removal of SPO11 and Resection of 5' Ends of DNA (yeast)

Class:Id	BlackBoxEvent:981784
_displayName	Removal of SPO11 and Resection of 5' Ends of DNA (yeast)
_doRelease	TRUE
_timestamp	2011-03-02 09:07:52
authored	[InstanceEdit:913923] May, B, 2010-07-19
catalystActivity	[CatalystActivity:981789] 3'-5'-DNA exonuclease activity of MRX:SAE2 Complex [nucleoplasm] [CatalystActivity:981783] DNA endonuclease activity of MRX:SAE2 Complex [nucleoplasm]
catalystActivityReference	[CatalystActivityReference:9643942] endodeoxyribonuclease activity of MRX:SAE2 Complex [nucleoplasm] Sae2 is an endonuclease that processes hairpin DNA cooperatively with the Mre11/Rad50/Xrs2 complex
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:981786] May, B, 2010-10-27
edited	[InstanceEdit:913923] May, B, 2010-07-19
input	[Complex:981780] SPO11 Covalently Attached to Double-strand Break [nucleoplasm] [Saccharomyces cerevisiae]
isChimeric	FALSE
literatureReference	[LiteratureReference:913298] Endonucleolytic processing of covalent protein-linked DNA double-strand breaks [LiteratureReference:981762] Processing of meiotic DNA double strand breaks requires cyclin-dependent kinase and multiple nucleases [LiteratureReference:981742] Sae2p phosphorylation is crucial for cooperation with Mre11p for resection of DNA double-strand break ends during meiotic recombination in Saccharomyces cerevisiae [LiteratureReference:981741] Functional interactions between Sae2 and the Mre11 complex [LiteratureReference:981732] The Rad50 hook domain is a critical determinant of Mre11 complex functions [LiteratureReference:981753] The nuclease activity of Mre11 is required for meiosis but not for mating type switching, end joining, or telomere maintenance
modified	[InstanceEdit:981790] May, B, 2010-10-27 [InstanceEdit:1008999] May, B, 2010-11-11 [InstanceEdit:1086964] May, B, 2010-11-29 [InstanceEdit:1220550] May, B, 2011-02-20 [InstanceEdit:1221624] May, B, 2011-02-25 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Removal of SPO11 and Resection of 5' Ends of DNA (yeast)
output	[OtherEntity:75156] 3' overhanging DNA at resected DSB ends [nucleoplasm] [Complex:981778] SPO11:oligonucleotide [nucleoplasm] [Saccharomyces cerevisiae]
releaseDate	2011-03-15
reviewed	[InstanceEdit:1221628] Bolcun-Filas, E, 2011-02-25 [InstanceEdit:1181360] Cohen, PE, 2011-02-04 [InstanceEdit:1181371] Holloway, JK, 2011-02-04 [InstanceEdit:1221625] Lyndaker, A, 2011-02-25 [InstanceEdit:1181380] Schimenti, JC, 2011-02-04 [InstanceEdit:1221623] Strong, E, 2011-02-25
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:68322] Saccharomyces cerevisiae
stableIdentifier	[StableIdentifier:1224925] R-SCE-981784.3
summation	[Summation:981787] SPO11 forms a dimer and each subunit cleaves a single strand...
(inferredFrom)	[BlackBoxEvent:9023941] MRN:CtIP endonucleolytically cleaves single-strand DNA 3' to SPO11 [Homo sapiens] [BlackBoxEvent:9023943] MRN:CtIP exonucleolytically hydrolyzes DNA 3' to SPO11 and SPO11:double-strand break dissociates to SPO11:oligonucleotide and resected 5' end [Homo sapiens]
(replacementInstances)	[_Deleted:9032440] Deletion of instance: 5334727
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