Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person Tet3 supplied by maternal cytoplasm is the major enzyme cata...
| Class:Id | Summation:9817701 |
|---|---|
| _displayName | Tet3 supplied by maternal cytoplasm is the major enzyme cata... |
| _timestamp | 2023-01-05 02:40:49 |
| created | [InstanceEdit:9817627] May, Bruce, 2022-09-26 |
| literatureReference | [LiteratureReference:5223024] Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation |
| modified | [InstanceEdit:9822777] May, Bruce, 2022-12-28 [InstanceEdit:9823275] May, Bruce, 2023-01-05 |
| text | Tet3 supplied by maternal cytoplasm is the major enzyme catalyzing oxidation of 5-methylcytidine to 5-hydroxymethylcytidine in the male pronucleus (Gu et al. 2011, Wossidlo et al. 2011, Iqbal et al. 2011, Santos et al. 2013). Tet3-catalyzed demethylation is part of the second phase of active demethylation in the male pronucleus (Santos et al. 2013). The first phase appears to be catalyzed by cytidine deamination followed by base excision repair (Santos et al. 2013). Accumulation of 5-hydroxymethylcytidine requires the cytosine methylases Dnmt3a and Dnmt1 (Amouroux et al. 2016). In mouse embryonic stem cells 5-hydroxymethylcytidine is mostly associated with euchromatin and depends on pre-existing 5-methylcytidine (Ficz et al. 2011). Tet3 is associated with Stgp4 and Mettl23 bound to chromatin (Hatanaka et al. 2017). Tet1 and Tet2 may also play a role in production of hydroxycytidine in the paternal genome (Ficz et al. 2011). |
| (summation) | [Reaction:9817463] Tet3 oxidizes 5-methylcytosine to 5-hydroxymethylcytosine in chromatin containing histone H3.3 dimethylated on lysine-9 [Mus musculus] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by Tet3 supplied by maternal cytoplasm is the major enzyme cata... (9817701)
