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Details on Person Delta-catenin (CTNND1, also known as p120 or CAS), was shown...
| Class:Id | Summation:9817327 |
|---|---|
| _displayName | Delta-catenin (CTNND1, also known as p120 or CAS), was shown... |
| _timestamp | 2025-01-22 04:14:24 |
| created | [InstanceEdit:9817326] Orlic-Milacic, Marija, 2022-09-15 |
| literatureReference | [LiteratureReference:9934388] Identification of a new catenin: the tyrosine kinase substrate p120cas associates with E-cadherin complexes [LiteratureReference:9933208] Contextual binding of p120ctn to E-cadherin at the basolateral plasma membrane in polarized epithelia [LiteratureReference:9762154] Adhesive but not lateral E-cadherin complexes require calcium and catenins for their formation [LiteratureReference:9817335] α-Catenin contributes to the strength of E-cadherin-p120 interactions [LiteratureReference:9935122] The regulatory or phosphorylation domain of p120 catenin controls E-cadherin dynamics at the plasma membrane [LiteratureReference:9935144] Dynamic and static interactions between p120 catenin and E-cadherin regulate the stability of cell-cell adhesion |
| modified | [InstanceEdit:9817341] Orlic-Milacic, Marija, 2022-09-15 [InstanceEdit:9934405] Orlic-Milacic, Marija, 2025-01-08 [InstanceEdit:9935128] Orlic-Milacic, Marija, 2025-01-13 [InstanceEdit:9935146] Orlic-Milacic, Marija, 2025-01-13 [InstanceEdit:9936225] Orlic-Milacic, Marija, 2025-01-22 |
| text | Delta-catenin (CTNND1, also known as p120 or CAS), was shown to associate with CDH1 complexes that also contain CTNNA1 (alpha-catenin), CTNNB1 (beta-catenin), and JUP (plakoglobin or gamma-catenin) in the canine cell line MDCK (Reynolds et al. 1994). In MDCK cells, it was shown that CTNND1 only associates with CDH1 complexes at the basolateral plasma membrane, binding to the juxtamembrane domain (JMD) of CDH1 (Miranda et al. 2003). Human breast cancer cell line MDA-MB-468 is CTNNA1 deficient, and although it forms adherens junction-like structures, it is unable to form normal epithelial colonies. Interaction between CTNND1 and CDH1 in MDA-MB-468 cell line strengthens upon CTNNA1 reconstitution, implying intra-CDH1:catenin-complex interaction between CTNND1 and CTNNA1 that is abrogated in CTNND1 splicing isoforms that contain exon C, encoding amino acids 626-631 (Troyanovsky et al. 2011: human recombinant CTNND1 splicing isoforms, human recombinant CDH1 and human recombinant CTNNA1 were used). Constitutive phosphorylation of CTNND1 on serine/threonine residues was reported to affect its ability to interact with CDH1 at the plasma membrane and to stabilize CDH1 at adherens junctions (Fukumoto et al. 2008). Different splicing isoforms of CTNND1 may have different affinity for CDH1 (Fukumoto et al. 2008). A detailed crystal structure study of a recombinant human CTNND1 splicing isoform 4A and a recombinant JMD of human CDH1 reported that CTNND1 residues K401 and N478 were critical for interaction with CDH1 JMD, and that minimal sequence changes in the JMD, such as R749W substitution observed in hereditary diffuse gastric cancer, are predicted to disrupt the interaction (Ishiyama et al. 2010). |
| (summation) | [Reaction:9817325] CDH1 associates with CTNND1 [Homo sapiens] |
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No pathways have been reviewed or authored by Delta-catenin (CTNND1, also known as p120 or CAS), was shown... (9817327)
