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Details on Person DUX4, TPRXL, TPRX1, and TPRX2 bind the DUXB gene

Class:Id	Reaction:9817258
_displayName	DUX4, TPRXL, TPRX1, and TPRX2 bind the DUXB gene
_doRelease	TRUE
_timestamp	2023-08-08 17:56:12
authored	[InstanceEdit:9817262] May, Bruce, 2022-09-13
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9817247] May, Bruce, 2022-09-15
edited	[InstanceEdit:9817262] May, Bruce, 2022-09-13
input	[EntityWithAccessionedSequence:9816412] DUX4 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9817251] DUXB gene [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9818519] TPRX1 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9818475] TPRX2 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9818451] TPRXL [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9816444] Conserved roles of mouse DUX and human DUX4 in activating cleavage-stage genes and MERVL/HERVL retrotransposons [LiteratureReference:9818480] Translatome and transcriptome co-profiling reveals a role of TPRXs in human zygotic genome activation
modified	[InstanceEdit:9818552] May, Bruce, 2022-10-18 [InstanceEdit:9820789] May, Bruce, 2022-11-19 [InstanceEdit:9841067] May, Bruce, 2023-08-08
name	DUX4, TPRXL, TPRX1, and TPRX2 bind the DUXB gene
output	[Complex:9817272] DUX4:TPRXL:TPRX1:TPRX2:DUXB gene [nucleoplasm] [Homo sapiens]
precedingEvent	[BlackBoxEvent:9816369] Expression of DUX4 in the zygote [Homo sapiens] [Reaction:9816389] DPPA2, DPPA4 and TP53 bind the DUX4 gene cluster [Homo sapiens]
releaseDate	2023-09-13
reviewed	[InstanceEdit:9841065] Xie, Wei, 2023-08-08
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9817315] R-HSA-9817258.1
summation	[Summation:9820786] DUX4 (Hendrickson et al. 2017) and TRPXL, TRPX1, and TRPX2 (...
(hasEvent)	[Pathway:9819196] Zygotic genome activation (ZGA) [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9817941] Expression of DUXB in the embryo [Homo sapiens]
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No pathways have been reviewed or authored by DUX4, TPRXL, TPRX1, and TPRX2 bind the DUXB gene (9817258)