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Details on Person DUX4, TPRXL, TPRX1, TPRX2, EP300, and CREBBP bind the ZSCAN4 gene

Class:Id	Reaction:9816396
_displayName	DUX4, TPRXL, TPRX1, TPRX2, EP300, and CREBBP bind the ZSCAN4 gene
_doRelease	TRUE
_timestamp	2023-08-08 22:51:31
authored	[InstanceEdit:9816375] May, Bruce, 2022-09-07
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9816422] May, Bruce, 2022-09-12
edited	[InstanceEdit:9816375] May, Bruce, 2022-09-07
inferredFrom	[Reaction:9816416] Dux binds a Zscan4 gene [Mus musculus] [Reaction:9841076] Obox1,2,3,4,5,6,7,8 binds Zscan4a,d [Mus musculus]
input	[EntityWithAccessionedSequence:9816412] DUX4 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9816413] ZSCAN4 gene [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:193545] CREBBP [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:381325] EP300 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9818519] TPRX1 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9818475] TPRX2 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9818451] TPRXL [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9816414] DUX-family transcription factors regulate zygotic genome activation in placental mammals [LiteratureReference:9816448] DUX4 activates germline genes, retroelements, and immune mediators: implications for facioscapulohumeral dystrophy [LiteratureReference:9817280] DUX4 recruits p300/CBP through its C-terminus and induces global H3K27 acetylation changes [LiteratureReference:9817242] DUX4 is a multifunctional factor priming human embryonic genome activation [LiteratureReference:9818480] Translatome and transcriptome co-profiling reveals a role of TPRXs in human zygotic genome activation
modified	[InstanceEdit:9817324] May, Bruce, 2022-09-15 [InstanceEdit:9818552] May, Bruce, 2022-10-18 [InstanceEdit:9820789] May, Bruce, 2022-11-19 [InstanceEdit:9841067] May, Bruce, 2023-08-08 [InstanceEdit:9841122] May, Bruce, 2023-08-08
name	DUX4, TPRXL, TPRX1, TPRX2, EP300, and CREBBP bind the ZSCAN4 gene
output	[Complex:9816378] DUX4:TPRXL:TPRX1:TPRX2:EP300:CREBBP:ZSCAN4 gene [nucleoplasm] [Homo sapiens]
precedingEvent	[BlackBoxEvent:9816369] Expression of DUX4 in the zygote [Homo sapiens] [Reaction:9816389] DPPA2, DPPA4 and TP53 bind the DUX4 gene cluster [Homo sapiens]
releaseDate	2023-09-13
reviewed	[InstanceEdit:9841065] Xie, Wei, 2023-08-08
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9816456] R-HSA-9816396.1
summation	[Summation:9817279] DUX4 binds four sites in the upstream promoter and enhancer ...
(hasEvent)	[Pathway:9819196] Zygotic genome activation (ZGA) [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9818523] Expression of ZSCAN4 in the embryo [Homo sapiens]
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No pathways have been reviewed or authored by DUX4, TPRXL, TPRX1, TPRX2, EP300, and CREBBP bind the ZSCAN4 gene (9816396)