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Details on Person DPPA2, DPPA4 and TP53 bind the DUX4 gene cluster

Class:Id	Reaction:9816389
_displayName	DPPA2, DPPA4 and TP53 bind the DUX4 gene cluster
_doRelease	TRUE
_timestamp	2023-08-08 17:54:53
authored	[InstanceEdit:9816375] May, Bruce, 2022-09-07
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9816422] May, Bruce, 2022-09-12
edited	[InstanceEdit:9816375] May, Bruce, 2022-09-07
inferredFrom	[Reaction:9816449] Dppa2 and Dppa4 bind the Dux gene cluster [Mus musculus]
input	[EntityWithAccessionedSequence:9816401] DPPA2 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:452999] DPPA4 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9816438] DUX4 gene [nucleoplasm] [Homo sapiens] [Complex:349474] p-S15-TP53 Tetramer [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9816364] p53 convergently activates Dux/DUX4 in embryonic stem cells and in facioscapulohumeral muscular dystrophy cell models
modified	[InstanceEdit:9822251] May, Bruce, 2022-12-21 [InstanceEdit:9841067] May, Bruce, 2023-08-08
name	DPPA2, DPPA4 and TP53 bind the DUX4 gene cluster
output	[Complex:9816394] DPPA2:DPPA4:p-S15-TP53:DUX4 gene [nucleoplasm] [Homo sapiens]
releaseDate	2023-09-13
reviewed	[InstanceEdit:9841065] Xie, Wei, 2023-08-08
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9816454] R-HSA-9816389.1
summation	[Summation:9816418] Activated TP53 (phosphoSer15-TP53) binds a LTR10C repeat abo...
(hasEvent)	[Pathway:9819196] Zygotic genome activation (ZGA) [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9816369] Expression of DUX4 in the zygote [Homo sapiens]
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No pathways have been reviewed or authored by DPPA2, DPPA4 and TP53 bind the DUX4 gene cluster (9816389)