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Details on Person MCRIP1 forms a complex with CTBP1. Binding of MCRIP1 to CTBP...
| Class:Id | Summation:9815988 |
|---|---|
| _displayName | MCRIP1 forms a complex with CTBP1. Binding of MCRIP1 to CTBP... |
| _timestamp | 2024-12-07 13:39:57 |
| created | [InstanceEdit:9815986] Orlic-Milacic, Marija, 2022-08-31 |
| literatureReference | [LiteratureReference:9765962] MCRIP1, an ERK substrate, mediates ERK-induced gene silencing during epithelial-mesenchymal transition by regulating the co-repressor CtBP [LiteratureReference:9930961] MCRIP1 promotes the expression of lung-surfactant proteins in mice by disrupting CtBP-mediated epigenetic gene silencing |
| modified | [InstanceEdit:9816026] Orlic-Milacic, Marija, 2022-08-31 [InstanceEdit:9930966] Orlic-Milacic, Marija, 2024-12-07 |
| text | MCRIP1 forms a complex with CTBP1. Binding of MCRIP1 to CTBP1 prevents formation of the complex between ZEB1 and CTBP1. Phosphorylation of MCRIP1 by activated MAPKs (ERKs) prevents association of MCRIP1 with CTBP1 (Ichikawa et al. 2015). MCRIP1 is also able to form a complex with CTBP2, but the biological significance of this complex is unknown (Ichikawa et al. 2015). Mouse Mcrip1 and Ctbp1/Ctbp2 were also shown to interact, with Mcrip1 competitively inhibiting binding of other transcription factors to Ctbp1 (Weng et al. 2019). |
| (summation) | [Reaction:9765974] MCRIP1 binds CTBP1 [Homo sapiens] |
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No pathways have been reviewed or authored by MCRIP1 forms a complex with CTBP1. Binding of MCRIP1 to CTBP... (9815988)
