Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person EZH2, a component of the PRC2 histone methyltransferase comp...

Class:IdSummation:9815884
_displayNameEZH2, a component of the PRC2 histone methyltransferase comp...
_timestamp2024-12-15 12:38:25
created[InstanceEdit:9815883] Orlic-Milacic, Marija, 2022-08-30
literatureReference[LiteratureReference:9764977] Snail2/Slug cooperates with Polycomb repressive complex 2 (PRC2) to regulate neural crest development
[LiteratureReference:9764994] Tumor-secreted Hsp90 subverts polycomb function to drive prostate tumor growth and invasion
[LiteratureReference:9764944] Long non-coding RNA HOTAIR promotes tumor cell invasion and metastasis by recruiting EZH2 and repressing E-cadherin in oral squamous cell carcinoma
[LiteratureReference:9764986] Long non-coding RNA HOTAIR mediates the switching of histone H3 lysine 27 acetylation to methylation to promote epithelial-to-mesenchymal transition in gastric cancer
[LiteratureReference:9765775] Long non-coding RNA LINC01133 represses KLF2, P21 and E-cadherin transcription through binding with EZH2, LSD1 in non small cell lung cancer
[LiteratureReference:9765000] Long noncoding RNA metastasis-associated lung adenocarcinoma transcript 1 cooperates with enhancer of zeste homolog 2 to promote hepatocellular carcinoma development by modulating the microRNA-22/Snail family transcriptional repressor 1 axis
[LiteratureReference:9764931] Long Noncoding RNA MRPL23-AS1 Promotes Adenoid Cystic Carcinoma Lung Metastasis
[LiteratureReference:9764963] The long non-coding RNA SNHG1 promotes bladder cancer progression by interacting with miR-143-3p and EZH2
[LiteratureReference:9764959] MUC1-C activates EZH2 expression and function in human cancer cells
[LiteratureReference:9768257] Polycomb complex 2 is required for E-cadherin repression by the Snail1 transcription factor
[LiteratureReference:9765827] G9a orchestrates PCL3 and KDM7A to promote histone H3K27 methylation
[LiteratureReference:9767907] EZH2 supports nasopharyngeal carcinoma cell aggressiveness by forming a co-repressor complex with HDAC1/HDAC2 and Snail to inhibit E-cadherin
modified[InstanceEdit:9815901] Orlic-Milacic, Marija, 2022-08-30
[InstanceEdit:9815904] Orlic-Milacic, Marija, 2022-08-30
[InstanceEdit:9930831] Orlic-Milacic, Marija, 2024-12-06
[InstanceEdit:9930833] Orlic-Milacic, Marija, 2024-12-06
[InstanceEdit:9932008] Orlic-Milacic, Marija, 2024-12-15
[InstanceEdit:9932011] Orlic-Milacic, Marija, 2024-12-15
[InstanceEdit:9932012] Orlic-Milacic, Marija, 2024-12-15
textEZH2, a component of the PRC2 histone methyltransferase complex (the core complex is composed of EZH2, EED2, RBBP4 or RBBP7, and SUZ12) binds the promoter of the CDH1 (E-cadherin) gene. Binding of both endogenous EZH2 and EED2 to the endogenous CDH1 gene promoter was demonstrated by chromatin immunoprecipitation (ChIP) in human cancer cells. In response to TGF-beta stimulation, EED2 levels increase and promote increased occupancy of the CDH1 promoter by EZH2 (Oktyabri et al. 2014). SNAI1 (Snail) (Herranz et al. 2008; Tong et al. 2012) and/or SNAI2 (Slug) (Tien et al. 2015) may be involved in the recruitment of the PRC2 complex to the CDH1 gene promoter. Histone-lysine N-methyltransferase EHMT2 may facilitate the recruitment of the PRC2 complex to the CDH1 gene promoter (Pan et al. 2015). Secreted extracellular HSP90 (eHSP90) may promote recruitment of EZH2 to the CDH1 gene promoter (Nolan et al. 2015). MUC1 (Mucin 1) was also reported to target EZH2 to the CDH1 gene promoter (Rajabi et al. 2017). Several long non-coding RNAs (lncRNAs) were reported to direct PRC2 to CDH1 gene promoter, including HOTAIR (HOX transcript antisense RNA) (Wu et al. 2015; Song et al. 2019), LINC01133 (Zang et al. 2016), MALAT1 (metastasis-associated lung adenocarcinoma transcript 1) (Chen et al. 2020), SNHG1 (small nucleolar RNA host gene 1) (Xiang et al. 2020), and MRPL23-AS1 (MRPL21 antisense RNA 1) (Chen et al. 2020).
(summation)[Reaction:9764930] PRC2 (EZH2) core complex binds CDH1 gene promoter [Homo sapiens]
[Change default viewing format]
No pathways have been reviewed or authored by EZH2, a component of the PRC2 histone methyltransferase comp... (9815884)
Follow Reactome