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Details on Person Factor I (CFI) cleaves the truncated alpha (a') chain of C4b...

Class:IdSummation:981509
_displayNameFactor I (CFI) cleaves the truncated alpha (a') chain of C4b...
_timestamp2016-01-21 13:07:37
created[InstanceEdit:981504] Jupe, S, 2010-10-21
literatureReference[LiteratureReference:981516] Human C4-binding protein. II. Role in proteolysis of C4b by C3b-inactivator
[LiteratureReference:981511] Phylogeny of C4b-C3b cleaving activity: similar fragmentation patterns of human C4b and C3b produced by lower animals
[LiteratureReference:977617] Factor I-dependent inactivation of human complement C4b of the classical pathway by C3b/C4b receptor (CR1, CD35) and membrane cofactor protein (MCP, CD46)
modified[InstanceEdit:981518] Jupe, S, 2010-10-21
[InstanceEdit:981705] Jupe, S, 2010-10-26
[InstanceEdit:8852841] Jupe, Steve, 2016-01-21
textFactor I (CFI) cleaves the truncated alpha (a') chain of C4b between Arg-1336 and Asn-1337 and then again between Arg-956 and Thr-957, producing a 16 kDa fragment known as alpha4, derived from the C terminus of the a' chain, followed by a 27 kDa alpha3 fragment. The remaining alpha 2 (C4d) fragment stays covalently bound to the cell membrane while the complex of disulfide-linked alpha3, alpha4, beta chain and gamma chain are released (C4c) into the fluid phase (Fujita et al. 1978).
(summation)[Reaction:977615] Factor I inactivates MCP/CR1-bound C4b/C3b [Homo sapiens]
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