Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:P37837-1 TALDO1
| Class:Id | ReferenceIsoform:9814913 |
|---|---|
| _chainChangeLog | chain:1-337 for 9814913 added on Mon August 15 2022 |
| _displayName | UniProt:P37837-1 TALDO1 |
| _timestamp | 2025-08-15 21:26:54 |
| chain | chain:1-337 |
| checksum | 8CB4992AEF364E64 |
| comment | FUNCTION Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate (PubMed:18687684, PubMed:8955144). Not only acts as a pentose phosphate pathway enzyme, but also affects other metabolite pathways by altering its subcellular localization between the nucleus and the cytoplasm (By similarity).CATALYTIC ACTIVITY D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + beta-D-fructose 6-phosphatePATHWAY Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3.SUBUNIT Homodimer (PubMed:10869557). Heterodimer with isoform 2 (By similarity). Interacts with KPNA1 and KPNA4 (By similarity).INTERACTION Shuttles between the nucleus and the cytoplasm. Actively transported into the nucleus in an importin alpha/beta-dependent manner. Exported into the cytoplasm by CRM1.SUBCELLULAR LOCATION Imported into the nucleus when incorporated in isoform 1/isoform 2 homodimer.ALTERNATIVE PRODUCTS The first 10 amino acids are essential for nuclear localization.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the transaldolase family. Type 1 subfamily. |
| created | [InstanceEdit:9796772] Weiser, Joel |
| description | recommendedName: Transaldolase ecNumber evidence="4 6"2.2.1.2 |
| geneName | TALDO1 TAL TALDO TALDOR |
| identifier | P37837 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative initiation Cytoplasm Disease variant Nucleus Pentose shunt Phosphoprotein Proteomics identification Reference proteome Schiff base Transferase |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | TALDO1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8950404] ENSEMBL:ENSG00000177156 TALDO1 [Homo sapiens] |
| secondaryIdentifier | TALDO_HUMAN B2R8M2 O00751 Q8WV32 Q8WZ45 |
| sequenceLength | 337 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | P37837-1 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P37837-1 TALDO1 (9814913)
