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| Class:Id | ReferenceGeneProduct:98000 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Sat February 7 2015;chain:2-187 added on Sat February 7 2015;peptide:2-12 added on Sat February 7 2015;initiator methionine:1 for 98000 removed on Fri Nov 03 2023;initiator methionine: for 98000 added on Fri Nov 03 2023;initiator methionine: for 98000 removed on Fri Aug 15 2025;initiator methionine:1 for 98000 added on Fri Aug 15 2025 |
| _displayName | UniProt:P31044 Pebp1 |
| _timestamp | 2025-08-15 21:02:08 |
| chain | initiator methionine:1 chain:2-187 peptide:2-12 |
| checksum | F2BF053FE34B8056 |
| comment | FUNCTION Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation (By similarity).FUNCTION HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be mediated by a specific receptor.SUBUNIT Has a tendency to form dimers by disulfide cross-linking. Interacts with RAF1 and this interaction is enhanced if RAF1 is phosphorylated on residues 'Ser-338', 'Ser-339', 'Tyr-340' and 'Tyr-341'. Interacts with ALOX15; in response to IL13/interleukin-13, prevents the interaction of PEBP1 with RAF1 to activate the ERK signaling cascade (By similarity).SUBCELLULAR LOCATION Major component of epididymal secretions and sperm plasma membranes. It is present in cytosols from a variety of other tissues. Highly expressed in brain.MISCELLANEOUS Seems to be associated with memory and learning disorder.SIMILARITY Belongs to the phosphatidylethanolamine-binding protein family. |
| description | recommendedName: Phosphatidylethanolamine-binding protein 1 shortName: PEBP-1 alternativeName: 23 kDa morphine-binding protein alternativeName: HCNPpp alternativeName: P23K component recommendedName: Hippocampal cholinergic neurostimulating peptide shortName: HCNP /component |
| geneName | Pebp1 Pbp Pebp |
| identifier | P31044 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation ATP-binding Cytoplasm Direct protein sequencing Disulfide bond Lipid-binding Membrane Nucleotide-binding Phosphoprotein Protease inhibitor Reference proteome Serine protease inhibitor |
| modified | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | Pebp1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | PEBP1_RAT P31045 |
| sequenceLength | 187 |
| species | [Species:48895] Rattus norvegicus |
| (referenceEntity) | [EntityWithAccessionedSequence:113477] phospho-RKIP [cytosol] [Rattus norvegicus] [EntityWithAccessionedSequence:113479] RKIP [cytosol] [Rattus norvegicus] [EntityWithAccessionedSequence:197501] Phospho-Pebp1 [cytosol] [Rattus norvegicus] [EntityWithAccessionedSequence:197536] Pebp1 [cytosol] [Rattus norvegicus] |
| (referenceSequence) | [ModifiedResidue:113475] O-phospho-L-serine at 153 [ModifiedResidue:197508] O-phospho-L-serine at 153 |
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