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Details on Person UniProt:Q21126 meg-1
| Class:Id | ReferenceGeneProduct:9797521 |
|---|---|
| _chainChangeLog | chain:1-636 for 9797521 added on Mon August 15 2022 |
| _displayName | UniProt:Q21126 meg-1 |
| _timestamp | 2023-11-03 15:37:37 |
| chain | chain:1-636 |
| checksum | 8ECCABA1901818BF |
| comment | FUNCTION P granule component, which acts redundantly with P granule component meg-2 to promote P granule segregation during embryogenesis, and germ cell proliferation and differentiation in larval stages (PubMed:18202375, PubMed:21305687, PubMed:25535836). In its phosphorylated form, and together with meg-2, promotes the disassembly of zygotic P granules in the anterior cytoplasm of pre-gastrulation embryos (PubMed:25535836). In its dephosphorylated form, and together with meg-2, promotes the assembly and accumulation of zygotic P granules in the posterior cytoplasm of pre-gastrulation embryos (PubMed:25535836). May function with the nanos family members nos-2 and nos-3 to promote germ cell proliferation during larval development (PubMed:21305687). Required for fertility (PubMed:18202375, PubMed:21305687).SUBUNIT Interacts with pptr-1, pptr-2 and pgl-1.SUBCELLULAR LOCATION Localizes to P granules in embryogenesis (PubMed:18202375). Localization to P granules may depend on mes-1 (PubMed:18202375).TISSUE SPECIFICITY Not expressed in the adult germline or in any somatic tissues.DEVELOPMENTAL STAGE Expressed in the P lineage during embryogenesis (PubMed:18202375). First expressed at the 4- to 8-cell stage, and expression remains throughout the remaining P cell divisions in P2, P3 and P4 cells, and subsequently in primordial germ cells Z2 and Z3 (PubMed:18202375). Expression begins to diminish at the 100-cell stage (PubMed:18202375).PTM Phosphorylated by mbk-2, which promotes the disassembly of zygotic P granules in the anterior cytoplasm of pre-gastrulation embryos (PubMed:25535836). Dephosphorylated by a phosphatase complex containing the PP2A regulatory subunit pptr-1, which promotes the assembly and accumulation of zygotic P granules in the posterior cytoplasm of pre-gastrulation embryos (PubMed:25535836).DISRUPTION PHENOTYPE RNAi-mediated knockdown results in sterility, and in P granule segregation defects (PubMed:18202375). Simultaneous RNAi-mediated knockdown of meg-1 and meg-2 results in defects in P granule disassembly in the anterior cytoplasm of the P1 blastomere causing some P granules to be mis-segregated to somatic blastomeres (PubMed:25535836). |
| created | [InstanceEdit:9796772] Weiser, Joel |
| description | recommendedName: fullName evidence="6"Protein meg-1 alternativeName: fullName evidence="5"Maternal effect germ cell defective 1 |
| geneName | meg-1 K02B9.1 |
| identifier | Q21126 |
| isSequenceChanged | FALSE |
| keyword | Developmental protein Phosphoprotein Reference proteome |
| modified | [InstanceEdit:9819394] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 |
| name | meg-1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | MEGG1_CAEEL |
| sequenceLength | 636 |
| species | [Species:68320] Caenorhabditis elegans |
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No pathways have been reviewed or authored by UniProt:Q21126 meg-1 (9797521)
