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Details on Person CYLD Limits Lys63- and Met1-Linked Ubiquitin at Receptor Complexes to Regulate Innate Immune Signaling

Class:Id	LiteratureReference:9796703
_displayName	CYLD Limits Lys63- and Met1-Linked Ubiquitin at Receptor Complexes to Regulate Innate Immune Signaling
_timestamp	2022-08-12 10:49:11
author	[Person:9796366] Hrdinka, Matous [Person:5661508] Fiil, Berthe Katrine [Person:9796709] Zucca, Mattia [Person:9796369] Leske, Derek [Person:9796375] Bagola, Katrin [Person:9796711] Yabal, Monica [Person:5661513] Elliott, Paul R [Person:5661502] Damgaard, Rune Busk [Person:2586662] Komander, David [Person:9710664] Jost, Philipp J [Person:9796389] Gyrd-Hansen, Mads
created	[InstanceEdit:9796707] Shamovsky, Veronica, 2022-08-12
journal	Cell Rep
pages	2846-58
pubMedIdentifier	26997266
title	CYLD Limits Lys63- and Met1-Linked Ubiquitin at Receptor Complexes to Regulate Innate Immune Signaling
volume	14
year	2016
(literatureReference)	[CatalystActivityReference:9818832] Met1-linked polyubiquitin deubiquitinase activity of TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] CYLD Limits Lys63- and Met1-Linked Ubiquitin at Receptor Complexes to Regulate Innate Immune Signaling [CatalystActivityReference:9818966] Lys63-specific deubiquitinase activity of TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] CYLD Limits Lys63- and Met1-Linked Ubiquitin at Receptor Complexes to Regulate Innate Immune Signaling [RegulationReference:9820384] Negative regulation by 'TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane]' CYLD Limits Lys63- and Met1-Linked Ubiquitin at Receptor Complexes to Regulate Innate Immune Signaling [Summation:9796348] The N-terminal methionine-linked ubiquitin (Met1-Ub) chains,... [Summation:9817393] Binding of TNFα to TNF receptor 1 (TNFR1) induces the sequen... [Summation:9818977] Binding of TNFα to TNF receptor 1 (TNFR1) induces the sequen... [BlackBoxEvent:9818975] CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex [Homo sapiens]
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