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Details on Person CDH1 expression is repressed by binding of SNAI2, also known...
| Class:Id | Summation:9796540 |
|---|---|
| _displayName | CDH1 expression is repressed by binding of SNAI2, also known... |
| _timestamp | 2024-12-05 16:58:39 |
| created | [InstanceEdit:9796541] Orlic-Milacic, Marija, 2022-08-10 |
| modified | [InstanceEdit:9857458] Rothfels, Karen, 2024-01-04 [InstanceEdit:9930699] Orlic-Milacic, Marija, 2024-12-05 |
| text | CDH1 expression is repressed by binding of SNAI2, also known as SLUG or SNAIL2, to E-boxes in the promoter, as demonstrated by EMSA and ChIP in MDCK cells and in synovial sarcoma cell lines (Hayashida et al, 2006; Saito et al, 2006). By a reporter assay, utilizing human CDH1 gene promoter and human SNAI2 (SLUG), it was demonstrated that SNAI2 directly represses CDH1 gene transcription (Hajra et al. 2002). Overexpression of SNAI2 represses transcription of endogenous CDH1 gene in human breast cancer cell lines, and the expression levels of SNAI2 and CDH1 in breast cancer cell lines are inversely correlated (Hajra et al. 2002). |
| (summation) | [BlackBoxEvent:9768484] SNAI2 represses CDH1 gene transcription [Homo sapiens] |
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