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Details on Person Cipro is oxidized to oxo-Cipro

Class:Id	BlackBoxEvent:9794840
_displayName	Cipro is oxidized to oxo-Cipro
_doRelease	TRUE
_timestamp	2022-11-09 22:57:46
authored	[InstanceEdit:9794829] Stephan, Ralf, 2022-07-21
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9794833] Stephan, Ralf, 2022-07-21
edited	[InstanceEdit:9795211] Stephan, Ralf, 2022-08-01
input	[SimpleEntity:9793625] Cipro [cytosol] [SimpleEntity:29368] O2 [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:9793523] Ciprofloxacin. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use [LiteratureReference:9794832] The biotransformation of nitrogen containing xenobiotics to lactams [LiteratureReference:9794835] Metabolism of gyrase inhibitors [LiteratureReference:9794836] Biotransformation and bioactivation reactions of alicyclic amines in drug molecules [LiteratureReference:9794487] Comparison of high-pressure liquid chromatography and bioassay for determination of ciprofloxacin in serum and urine [LiteratureReference:9794987] Ciprofloxacin greatly increases concentrations and hypotensive effect of tizanidine by inhibiting its cytochrome P450 1A2-mediated presystemic metabolism [LiteratureReference:9794994] The effect of ciprofloxacin on theophylline pharmacokinetics in healthy subjects [LiteratureReference:9794999] The effect of cytochrome P450 metabolism on drug response, interactions, and adverse effects [LiteratureReference:9794520] Pharmacokinetics of gyrase inhibitors, Part 2: Renal and hepatic elimination pathways and drug interactions
modified	[InstanceEdit:9794985] Stephan, Ralf, 2022-07-25 [InstanceEdit:9795000] Stephan, Ralf, 2022-07-25 [InstanceEdit:9795132] Stephan, Ralf, 2022-07-28 [InstanceEdit:9795148] Stephan, Ralf, 2022-07-29 [InstanceEdit:9795213] Stephan, Ralf, 2022-08-01 [InstanceEdit:9795217] Stephan, Ralf, 2022-08-01 [InstanceEdit:9820564] Matthews, Lisa, 2022-11-09 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Cipro is oxidized to oxo-Cipro
output	[SimpleEntity:29356] H2O [cytosol] [SimpleEntity:9794837] oxo-Cipro [cytosol]
precedingEvent	[Reaction:9795207] SLC22A1 transports Cipro into hepatic cell [Homo sapiens] [BlackBoxEvent:9794414] Basolateral transport of Cipro to extracellular space [Homo sapiens] [Reaction:9794475] Cipro:ALB dissociates [Homo sapiens]
releaseDate	2022-12-07
reviewed	[InstanceEdit:9820563] Thorn, Caroline F, 2022-11-09
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9794846] R-HSA-9794840.2
summation	[Summation:9794993] Oxo-Cipro (oxociprofloxacin, M3) is a major metabolite of Ci...
(hasEvent)	[Pathway:9793528] Ciprofloxacin ADME [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9795153] Basolateral excretion of oxo-Cipro [Homo sapiens]
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No pathways have been reviewed or authored by Cipro is oxidized to oxo-Cipro (9794840)